Vaginal Estrogen Cream is formulated to treat the genitourinary symptoms of menopause (GSM). This includes vaginal dryness, thinning of the vaginal walls (atrophy), itching, burning, and pain during intercourse (dyspareunia). It may also help reduce the frequency of recurrent urinary tract infections (UTIs).

During menopause, declining estrogen levels cause the vaginal tissues to become thinner, less elastic, and drier. Vaginal Estrogen Cream delivers a low dose of bioidentical estrogen directly to these tissues, helping restore their thickness, lubrication, and natural function.

Vaginal Estrogen Cream is applied directly to the vaginal canal to specifically target urogenital symptoms, while hormone therapy body cream is used on external skin, such as the wrists, for systemic absorption.

The cream is typically applied to the vagina using the supplied applicator. Your physician will provide a specific dosing schedule — often daily for the first few weeks, then reduced to a few times a week for maintenance.

Most women begin to feel relief from symptoms like dryness and itching within a few weeks. Full benefits, including restored vaginal tissue health and reduced pain during intercourse, may take up to 8–12 weeks.

Vaginal Estrogen Cream is best applied after intercourse to avoid timing concerns. The cream is dispensed inside the vagina at night before sleep, which allows time for proper absorption with less interruption. When the cream is used before intercourse, waiting at least 1–2 hours allows the medication to settle. For oral sex, a longer window is recommended — about 4 hours — to limit residual transfer.

There’s a small possibility that trace amounts of the cream may come into contact with your partner during sexual activity.

Vaginal Estrogen Cream is primarily used to relieve localized symptoms of menopause like dryness, itching, and pain during intercourse. By improving vaginal health and comfort, it may indirectly enhance libido or desire by making sexual activity more enjoyable.

Because vaginal estrogen is a localized treatment with very low systemic absorption, side effects are uncommon. Some women may experience temporary breast tenderness or light spotting when starting treatment. If you experience any persistent side effects, please consult with your Winona physician.

Yes, the estradiol used in our Vaginal Estrogen Cream is bioidentical, meaning it’s molecularly identical to the estrogen your body naturally produces.

Vaginal Estrogen Cream is a prescription-only medication. A physician’s guidance ensures the treatment is appropriate for your symptoms and that the correct dose is used. Over-the-counter options are typically non-hormonal moisturizers, not medications.

If you miss a dose, apply it as soon as you remember. However, if it’s closer to the time of your next scheduled dose, skip the missed one and continue your regular routine. Do not use a double dose.

Unfortunately, Winona cannot provide additional applicators. You can purchase them online from vendors like Amazon if you need more.

You can get your prescription by completing our online onboarding process. This starts with a free intake where you'll answer questions about your health and symptoms. A board-certified doctor will then review your information to determine if you are a candidate for treatment and, if so, will issue a prescription for Vaginal Estrogen Cream.

Once your prescription is issued, there’s a 24-hour review period before the pharmacy begins processing your order. The pharmacy typically prepares your medication within 1–3 business days, followed by shipping, which takes another 1–3 business days. On average, most patients receive their Vaginal Estrogen Cream within about 5 business days.

Your Vaginal Estrogen Cream is delivered directly to your door. Standard shipping is free on all prescriptions. If you need your medication sooner, expedited options are available at checkout, including USPS Priority (2–3 business days) or FedEx Overnight for an additional fee.

While Winona is currently unable to bill insurance companies directly, you can use your HSA (Health Savings Account) or FSA (Flexible Spending Account) card to pay for your Vaginal Estrogen Cream at checkout. You’ll also have access to receipts and documentation that you can use to submit and file a claim with your insurance provider for possible reimbursement.

The active ingredient in your Vaginal Estrogen Cream, estradiol, is FDA approved. The final medication itself is prepared for you by a state-licensed compounding pharmacy that follows strict quality standards. This allows for personalized dosages not available in pre-packaged, mass-produced medications.

Your treatment is personalized, and ongoing care is included. If you feel your dosage needs adjustment, you can discuss this with your doctor anytime via messaging in the secure Patient Portal. Adjustments are free, and your doctor will work with you to find the right dosage for your needs.

Your Winona subscription includes unlimited, 24/7 messaging with your board-certified doctor. You can ask questions about your Vaginal Estrogen Cream, discuss your symptoms, or request dosage adjustments at any time through the secure Patient Portal.

To reorder your Vaginal Estrogen Cream, log in to the Patient Portal and contact the Patient Care Team. Your physician will review and approve your request for additional refills before filling the prescription.