“Bi-est” is short for bi-estrogen and refers to a compounded blend of two estrogens: estriol (E3) and estradiol (E2). These work together to mimic the natural balance of estrogen in the body.

The “50/50” refers to the ratio of the two estrogens in the cream: 50% estriol (E3) and 50% estradiol (E2). This balanced formulation provides the benefits of both — estradiol for stronger symptom relief and estriol for a gentler, skin-friendly effect.

Winona’s Estrogen Body Cream is formulated to relieve systemic menopause symptoms. It’s highly effective at reducing hot flashes and night sweats, improving sleep quality, stabilizing mood, and protecting against bone loss.

Yes. Both the estriol and estradiol used in our creams are bioidentical, meaning they’re chemically identical to the hormones naturally produced by your body.

Estrogen cream delivers hormones through the skin for direct absorption, bypassing the liver and helping maintain stable hormone levels throughout the day. Pills, on the other hand, are processed through the liver before entering the bloodstream, which can sometimes lead to more noticeable side effects. Many women also prefer the simplicity of a once-daily cream over other methods.

Some women notice improvements in sleep and mood within just a few weeks. For symptoms like hot flashes and night sweats, it can take up to three months of consistent scheduled use to experience the full benefits.

Apply the cream to clean, dry, hair-free skin, avoiding the face and breasts. The inner thighs or forearms are ideal application sites.

Most women find it convenient to apply their estrogen cream in the morning after showering, but you can apply it at any time that fits your daily routine. The key is consistency — apply it at the same time each day to maintain steady hormone levels.

The cream is designed to absorb quickly into the skin. It typically takes about 30 minutes for the cream to be fully absorbed.

Wait at least 30 minutes before getting the application area wet. Waiting that long before showering or swimming helps ensure optimal absorption and consistent results.

If you miss a dose, apply it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.

Each prescription is personalized based on individual needs and symptoms. Your Winona physician will determine your specific dose and provide detailed information within the secure Patient Portal.

When prescribed at the appropriate dose, estrogen cream is generally well tolerated. Some women may experience mild side effects such as breast tenderness or bloating while their body adjusts. If side effects persist or you have any concerns, please discuss them with your Winona physician.

Yes. Hormone therapy can help manage weight changes related to hormonal fluctuations during menopause. However, it’s not a weight loss treatment. Any weight reduction that occurs is typically a result of improved hormone balance, which helps regulate metabolism and reduce water retention.

If you have a uterus, progesterone should be taken alongside estrogen. This combination helps protect the uterine lining from overgrowth, reducing the risk of cancer.

Over-the-counter creams usually contain weak estrogens called phytoestrogens. These ingredients are not regulated by the FDA and have limited clinical evidence of effectiveness. Winona’s Estrogen Body Cream is a powerful, proven medication containing bioidentical hormones that requires a prescription to ensure safety and effectiveness.

The bottle may appear less than full, but it contains the exact amount needed for the prescribed number of doses. Some space is intentionally left for the airless pump mechanism to properly dispense.

You can get your prescription by completing our online onboarding process. This starts with a free intake where you'll answer questions about your health and symptoms. A board-certified doctor will then review your information to determine if you are a candidate for treatment and, if so, will issue a prescription for Estrogen Body Cream.

Once your prescription is issued, there’s a 24-hour review period before the pharmacy begins processing your order. The pharmacy typically prepares your medication within 1–3 business days, followed by shipping, which takes another 1–3 business days. On average, most patients receive their Estrogen Body Cream within about 5 business days.

Your Estrogen Body Cream is delivered directly to your door. Standard shipping is free on all prescriptions. If you need your medication sooner, expedited options are available at checkout, including USPS Priority (2–3 business days) or FedEx Overnight for an additional fee.

While Winona is currently unable to bill insurance companies directly, you can use your HSA (Health Savings Account) or FSA (Flexible Spending Account) card to pay for your Estrogen Body Cream at checkout. You’ll also have access to receipts and documentation that you can use to submit and file a claim with your insurance provider for possible reimbursement.

The active ingredients in your Estrogen Body Cream, estradiol and estriol, are FDA approved. The final medication itself is prepared for you by a state-licensed compounding pharmacy that follows strict quality standards. This allows for personalized dosages not available in pre-packaged, mass-produced medications.

Your treatment is personalized, and ongoing care is included. If you feel your dosage needs adjustment, you can discuss this with your doctor anytime via messaging in the secure Patient Portal. Adjustments are free, and your doctor will work with you to find the right dosage for your needs.

Your Winona subscription includes unlimited, 24/7 messaging with your board-certified doctor. You can ask questions about your Estrogen Body Cream, discuss your symptoms, or request dosage adjustments at any time through the secure Patient Portal.

Your treatment is set up as a subscription, so refills for Estrogen Body Cream are automatically processed and shipped based on your treatment schedule — that way, you never run out. You can manage your subscription, change your shipping date, or cancel at any time.