Both hormones are necessary if you have a uterus. Estrogen helps relieve menopause symptoms, but on its own, it can cause the uterine lining to thicken. Progesterone prevents that overgrowth, reducing the risk of uterine cancer.

For women who need both hormones, this cream provides a convenient, single-application solution. It simplifies daily routine by delivering a balanced dose of both estrogen and progesterone at the same time, ensuring you get the benefits of estrogen along with the necessary uterine protection from progesterone.

The main benefit is convenience. A single cream delivering both estrogen and progesterone ensures a consistent, balanced dose each time. It also simplifies your daily routine and helps maintain even absorption across applications.

This cream is designed to treat a wide range of menopause symptoms. Estrogen is highly effective for hot flashes, night sweats, and bone loss, while progesterone provides uterine protection, improves sleep, and helps stabilize mood.

Yes. The estriol, estradiol, and progesterone used in our creams are all bioidentical, meaning they’re chemically identical to the hormones naturally produced by the body.

“Bi-est” is short for bi-estrogen and refers to a compounded blend of two estrogens: estriol (E3) and estradiol (E2). These work together to mimic the natural balance of estrogen in the body.

Apply the cream to a clean, dry, non-hair-bearing area of skin with good circulation, such as the inner thighs or forearms. Avoid the face, breasts, or broken/irritated skin. Because progesterone has a calming effect, applying the cream in the evening may help with sleep.

Evening application is best for most patients. The progesterone in the cream has a natural calming effect that supports restful sleep. Applying it at the same time each evening helps maintain steady hormone levels and consistent symptom relief.

Many women report improvements in sleep and mood within a few weeks. It may take up to three months of consistent use to experience the full benefits for symptoms like hot flashes and night sweats.

When prescribed at the right dose, this cream is generally well-tolerated. Mild side effects, such as breast tenderness or bloating, can occur as the body adjusts to the medication. Progesterone can also cause drowsiness, which is why evening use is recommended. If side effects persist or cause concern, please speak with your Winona physician.

Yes. A prescription ensures that a physician can tailor the hormone doses to your needs and monitor treatment for safety and effectiveness. These are potent, active medications and should only be used under medical supervision.

If you miss a dose, apply it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed one and continue your regular routine. Do not apply a double dose.

Yes, our progesterone is formulated without peanut products and is safe for women with peanut allergies.

The bottle may appear less than full, but it contains the exact amount needed for the prescribed number of doses. Some space is intentionally left to allow for proper dispensing.

You can get your prescription by completing our online onboarding process. This starts with a free intake where you'll answer questions about your health and symptoms. A board-certified doctor will then review your information to determine if you are a candidate for treatment and, if so, will issue a prescription for Estrogen Body Cream with Progesterone.

Once your prescription is issued, there’s a 24-hour review period before the pharmacy begins processing your order. The pharmacy typically prepares your medication within 1–3 business days, followed by shipping, which takes another 1–3 business days. On average, most patients receive their Estrogen Body Cream with Progesterone within about 5 business days.

Your Estrogen Body Cream with Progesterone is delivered directly to your door. Standard shipping is free on all prescriptions. If you need your medication sooner, expedited options are available at checkout, including USPS Priority (2–3 business days) or FedEx Overnight for an additional fee.

While Winona is currently unable to bill insurance companies directly, you can use your HSA (Health Savings Account) or FSA (Flexible Spending Account) card to pay for your Estrogen Body Cream with Progesterone at checkout. You’ll also have access to receipts and documentation that you can use to submit and file a claim with your insurance provider for possible reimbursement.

The active ingredients in your Estrogen Body Cream with Progesterone, such as estriol and progesterone USP, are FDA approved. The final medication itself is prepared for you by a state-licensed compounding pharmacy that follows strict quality standards. This allows for personalized dosages not available in pre-packaged, mass-produced medications.

Your treatment is personalized, and ongoing care is included. If you feel your dosage needs adjustment, you can discuss this with your doctor anytime via messaging in the secure Patient Portal. Adjustments are free, and your doctor will work with you to find the right dosage for your needs.

Your Winona subscription includes unlimited, 24/7 messaging with your board-certified doctor. You can ask questions about your Estrogen Body Cream with Progesterone, discuss your symptoms, or request dosage adjustments at any time through the secure Patient Portal.

Your treatment is set up as a subscription, so refills for Estrogen Body Cream with Progesterone are automatically processed and shipped based on your treatment schedule — that way, you never run out. You can manage your subscription, change your shipping date, or cancel at any time.