Estriol and tretinoin work together to address menopausal skin changes in different ways. Tretinoin is a powerful retinoid that helps skin renew itself faster, smoothing texture and reducing fine lines. Estriol is a gentle form of estrogen that helps rebuild the skin's foundation. It keeps the skin firm, hydrated, and elastic by supporting collagen and moisture production. Together, tretinoin and estriol help restore skin that has become thinner or drier during the menopause transition.

Most women notice that with regular evening use, this cream can help reduce fine lines and wrinkles, improve firmness and elasticity, even out skin tone, and boost hydration. Skin that has become thin or dry during menopause often feels softer, plumper, and more radiant over time.

While tretinoin is a powerful resurfacing agent, topical estriol works deeper to address the effects of declining estrogen. It helps rebuild the skin’s foundation by supporting collagen and elastin, improving elasticity, and enhancing hydration for a plumper, firmer appearance. Estriol also strengthens the skin barrier, making it look smoother and healthier, and its gentle nature makes it suitable for sensitive, mature skin.

Gradually integrate the product into a routine, starting with use 1–2 times per week in the evening and increasing frequency as tolerated.

A pea-sized amount is recommended to cover the entire face. Using more will not improve results and may increase the likelihood of irritation. A little goes a long way.

Skincare with active ingredients like tretinoin and estriol requires patience and consistency. Generally, visible improvements begin to appear within a few weeks, though significant results develop gradually over time.

Tretinoin is a retinoid that increases the skin’s sensitivity to ultraviolet (UV) rays. This raises the risk of sunburn and irritation. Applying the cream at night minimizes exposure to harmful UV radiation.

Tretinoin can increase UV sensitivity, making daily sunscreen use essential to protect the skin from irritation and sun damage.

Mild dryness or irritation is a common initial reaction when starting a tretinoin regimen. As the skin adjusts to tretinoin, these effects will resolve.

Avoid using other active ingredients like vitamin C, AHAs, BHAs, or azelaic acid. Also, don't use strong physical or chemical exfoliants. Apply the Estriol Face Cream with Tretinoin to dry skin only, as wet or damp skin may increase the absorption of active ingredients.

Estriol is a much weaker estrogen, making it ideal for sensitive facial tissue. It stimulates collagen and improves skin quality locally, without significant absorption into the bloodstream. Estradiol is a more potent estrogen typically used for systemic hormone replacement therapy.

No. The estriol in this cream is formulated for topical use and acts locally on the skin without systemic effects.

Yes. Both tretinoin and estriol are prescription-only ingredients. This ensures that a physician can assess your skin's needs and confirm if this treatment is appropriate and safe for you.

Yes. When used as directed by your physician, this cream is suitable for long-term use to help manage and prevent signs of hormonal skin aging during the menopausal transition and beyond.

You can get your prescription by completing our online onboarding process. This starts with a free intake where you'll answer questions about your health and symptoms. A board-certified doctor will then review your information to determine if you are a candidate for treatment and, if so, will issue a prescription for Estriol Face Cream with Tretinoin.

Once your prescription is issued, there is a 24-hour review period before the pharmacy begins processing your order. The pharmacy typically prepares your medication within 1–3 business days, followed by shipping, which takes another 1–3 business days. On average, most patients receive their Estriol Face Cream with Tretinoin within about 5 business days.

Your Estriol Face Cream with Tretinoin is delivered directly to your door. Standard shipping is free on all prescriptions. If you need your medication sooner, expedited options are available at checkout, including USPS Priority (2–3 business days) or FedEx Overnight for an additional fee.

While Winona is currently unable to bill insurance companies directly, you can use your HSA (Health Savings Account) or FSA (Flexible Spending Account) card to pay for your Estriol Face Cream with Tretinoin at checkout. You’ll also have access to receipts and documentation that you can use to submit and file a claim with your insurance provider for possible reimbursement.

The active ingredients in your face cream, estriol and tretinoin, are FDA approved. The final medication itself is prepared for you by a state-licensed compounding pharmacy that follows strict quality standards. This allows for personalized dosages not available in pre-packaged, mass-produced medications.

Your treatment is personalized, and ongoing care is included. If you feel your treatment needs adjustment, you can discuss this with your doctor anytime via messaging in the secure Patient Portal. Adjustments are free, and your doctor will work with you to find the right dosage for your needs.

Your Winona subscription includes unlimited, 24/7 messaging with your board-certified doctor. You can ask questions about your Estriol Face Cream with Tretinoin, request dosage adjustments, or explore Winona’s other treatments at any time through the secure Patient Portal.

Your treatment is set up as a subscription, so refills for Estriol Face Cream with Tretinoin are automatically processed and shipped based on your treatment schedule — that way, you never run out. You can manage your subscription, change your shipping date, or cancel at any time.