The Menopause Hour - Episode -22 (Aug 27 Jo)
Podcast

The Menopause Hour with Winona: Lunchtime Skincare with Jo: How to Layer Skincare Products (And What to Avoid) - Episode #22

Published: September, 2025

Host

Jo Cullen & Madi Baldwin

Applying the right products in the wrong order can quietly undercut a skincare routine's effectiveness. In Episode #22 of The Menopause Hour with Winona, Jo Cullen, Winona's Dermatology Nurse Practitioner, tackled exactly that. Hosted by Madi Baldwin in the second installment of a four-part Lunchtime Skincare series titled "Lunchtime Skincare with Jo: How to Layer Skincare Products (And What to Avoid)."

Jo walked listeners through the skin's layers, the correct order to apply serums, lotions, and creams, and how to build separate AM and PM routines. The episode covered the common layering mistakes that most often trip people up.


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Episode Details

  • Podcast: The Menopause Hour with Winona

  • Episode Number: 22

  • Episode Title: Episode #22: Lunchtime Skincare with Jo: How to Layer Skincare Products (And What to Avoid)

  • Host: Madi Baldwin

  • Presenter: Jo Cullen (Winona's Dermatology Nurse Practitioner)

  • Published Date: September 17, 2025

  • Episode Duration: 46 min 8 sec

  • Format: Jo's Skincare

  • Main Topics: Skincare layering order, Serums vs. creams, AM/PM routines

About The Menopause Hour with Winona Podcast

The Menopause Hour with Winona is a health and wellness podcast hosted by Winona's medical professionals, addressing the perimenopause and menopause questions patients bring to their own doctors every day.

The show moves between live Q&A sessions, doctor-to-doctor dialogues, skincare deep-dives, and real patient stories, covering symptoms, treatment options, and the science behind the menopause transition.

Visit The Menopause Hour on Buzzsprout.

About This Episode

Continuing the Lunchtime Skincare series, this episode tackled one of the most common skincare questions: what order should products actually go on in? Jo broke down the skin's three layers — epidermis, dermis, and hypodermis — and explained why lighter, smaller-molecule products like serums need to go on before thicker creams to reach the layers where they can do the most good.

She walked through building separate AM and PM routines, why vitamin C works best applied first thing in the morning, and why tretinoin should go on dry rather than damp skin to minimize irritation. Jo also addressed a common mistake — stacking too many active or exfoliating ingredients at once. She also cleared up the difference between hydration and moisturization, explaining why skipping moisturizer can backfire even for oily skin.

Learn more about skincare during menopause. 

Topics Covered

  • Why skincare layering order affects how well products absorb

  • The skin's three layers (epidermis, dermis, hypodermis) and where products actually work

  • Layering from thinnest to thickest: serums, gels, lotions, and creams explained

  • Why vitamin C works best as the first product applied in the morning

  • Building an AM routine: cleanse, prep, serum, eye cream, moisturizer, SPF

  • Building a PM routine: cleanse, prep, serum, eye cream, moisturizer

  • Why tretinoin should go on dry, not damp, skin

  • Avoiding "ingredient stacking" that leads to over-exfoliation and irritation

  • The difference between hydration (water) and moisturization (oil)

  • Why skipping moisturizer can actually increase oil production

  • Adjusting your routine order for sensitive or irritated skin

  • Rotating active ingredients to prevent overuse and irritation

Key Takeaways

Skincare should be layered from thinnest to thickest

Jo explained that lighter, smaller-molecule products like serums should go on first so they can absorb into the skin's deeper layers, while thicker creams applied last help seal those active ingredients in.

Vitamin C works best as the first product in a morning routine

Jo recommended applying vitamin C immediately after cleansing and prepping the skin, since delaying it behind other products slows how quickly it can address concerns like discoloration.

Tretinoin should go on dry skin to minimize irritation

Jo noted that applying tretinoin to still-damp skin tends to increase irritation, so waiting for the skin to fully dry after cleansing or using a prep product can make the product more comfortable to use.

Stacking too many active ingredients at once can backfire

Jo cautioned against combining multiple exfoliating or active products, like an acid cleanser, a glycolic toner, and a retinol, in the same routine, since the combination can irritate the skin rather than improve it.

Skipping moisturizer can make oily skin worse, not better

Jo explained that skin stripped of moisture often compensates by producing more oil, so using a moisturizer — even for oily skin — can help regulate oil production rather than add to it.


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Watch the full conversation on
The Menopause Hour with Winona with Jo Cullen & Madi Baldwin.

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