Twitches and spasms are most common in the thighs, calves, hands, arms, belly, ribcage, and the arches. They can affect part of a muscle, all of it, or even a group of muscles. Doctors aren't always sure why they happen, but a few common triggers can set them off.
Perimenopause and menopause do not directly cause muscles to twitch. However, anxiety and fatigue, which are common symptoms of menopause, can trigger the condition. Magnesium deficiency, dehydration, and rigorous exercise can also cause twitching muscles.
One of the most prominent reasons for skeletal muscle spasms and cramps is dehydration. As women enter menopause, the body finds it more difficult to retain water. The insufficient supply of water and minerals in the body can make your muscles irritable and spastic, which can lead to twitching.