[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"$fONQ0ZzJeaDl0Rsln6Pt32ovv9gN-ziBlOyQt_50BLWI":3,"journal-progesterone-with-estrogen":374,"accordion-request":706},[4,9,13,17,20,24,28,32,35,39,42,45,48,52,55,58,62,66,69,72,75,79,82,85,88,92,94,98,100,103,106,109,111,113,116,119,122,125,127,130,132,135,138,141,144,147,150,152,155,157,160,163,166,169,173,175,178,181,184,187,190,192,195,197,199,202,204,207,210,212,215,218,221,223,226,229,232,235,238,241,243,246,249,252,255,258,261,264,267,270,273,276,279,282,285,288,291,293,296,299,302,305,307,309,312,315,318,321,324,327,330,333,336,338,341,344,347,349,352,355,358,361,363,366,369,371],{"source":5,"target":6,"updated":7,"redirectType":8},"bywinona.com\u002Ffriends","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=FRIENDS&utm_source=podcast&htrafficsource=podcast&sl=friends-like-us","1775567855012","301",{"source":10,"target":11,"updated":12,"redirectType":8},"bywinona.com\u002Feligibilityyoutube","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?utm_source=youtube&utm_medium=social","1775567855005",{"source":14,"target":15,"updated":16,"redirectType":8},"bywinona.com\u002Fskinreport","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=SKINREPORT&utm_source=podcast&htrafficsource=podcast&sl=skinreport","1775567854999",{"source":18,"target":19,"updated":7,"redirectType":8},"https:\u002F\u002Fapp.bywinona.com\u002Feligibility\u002Ftwitter","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?utm_source=twitter&utm_medium=social",{"source":21,"target":22,"updated":23,"redirectType":8},"bywinona.com\u002Frosalita","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=ROSALITA20","1775567855002",{"source":25,"target":26,"updated":27,"redirectType":8},"bywinona.com\u002Fonboys","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=ONBOYS&utm_source=podcast&htrafficsource=podcast&sl=onboys","1775567855008",{"source":29,"target":30,"updated":31,"redirectType":8},"bywinona.com\u002Ffeminade","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=FEMINADE","1775567855003",{"source":33,"target":34,"updated":7,"redirectType":8},"bywinona.com\u002Frefer","https:\u002F\u002Fapp.bywinona.com\u002Freferral?utm_source=pharmacy-postcard",{"source":36,"target":37,"updated":38,"redirectType":8},"bywinona.com\u002Fliveqalinkedin","https:\u002F\u002Fbywinona.com\u002Fliveqa?utm_source=linkedin&utm_medium=social","1775567855006",{"source":40,"target":41,"updated":38,"redirectType":8},"bywinona.com\u002Ftestimonials","https:\u002F\u002Fbywinona.com\u002Fwinona-reviews",{"source":43,"target":44,"updated":16,"redirectType":8},"bywinona.com\u002Fliveqa-spotify","https:\u002F\u002Fbywinona.com\u002Fliveqa?utm_source=spotify&utm_medium=social",{"source":46,"target":47,"updated":23,"redirectType":8},"bywinona.com\u002Fbf40","https:\u002F\u002Fbywinona.com\u002Fblack-friday?utm_source=instagram&utm_content=bio-link",{"source":49,"target":50,"updated":51,"redirectType":8},"bywinona.com\u002Fkim","https:\u002F\u002Fbywinona.com?utm_source=kim&utm_campaign=affiliate&promocode=KIMREF25","1775567855007",{"source":53,"target":54,"updated":7,"redirectType":8},"bywinona.com\u002Fskincreambf","https:\u002F\u002Fapp.bywinona.com\u002Fhome?upsell=cream&utm_source=fb&utm_medium=social",{"source":56,"target":57,"updated":27,"redirectType":8},"bywinona.com\u002Fwinona-women","https:\u002F\u002Fwww.facebook.com\u002Fgroups\u002Fwinonawomen\u002F",{"source":59,"target":60,"updated":61,"redirectType":8},"bywinona.com\u002Fmenopause-symptoms\u002Ffacebook","https:\u002F\u002Fbywinona.com\u002Fjournal\u002Fmenopause-symptoms?utm_medium=social&utm_source=fb","1775567855011",{"source":63,"target":64,"updated":65,"redirectType":8},"bywinona.com\u002Fproduct\u002Festrogen-tablets","https:\u002F\u002Fbywinona.com\u002Fproduct\u002Festrogen-tablet","1775567855001",{"source":67,"target":68,"updated":61,"redirectType":8},"bywinona.com\u002Fproduct\u002Festriol-cream-with-tretinoin-galentines-wwg","https:\u002F\u002Fbywinona.com\u002Fproduct\u002Festriol-cream-with-tretinoin-galentines?utm_source=fb&utm_medium=social",{"source":70,"target":71,"updated":65,"redirectType":8},"bywinona.com\u002Fperi-menopause-quiz-results","https:\u002F\u002Fbywinona.com\u002Fam-i-in-menopause",{"source":73,"target":74,"updated":61,"redirectType":8},"bywinona.com\u002Fwebinars","https:\u002F\u002Fbywinona.com\u002Fwebinar?sl=sms&utm_source=sms&utm_campaign=abandoned-onboarding&utm_content=webinar",{"source":76,"target":77,"updated":78,"redirectType":8},"bywinona.com\u002Fv2\u002Fabout-us","https:\u002F\u002Fbywinona.com\u002Fabout-us","1775567855000",{"source":80,"target":81,"updated":65,"redirectType":8},"bywinona.com\u002Fhormonal-menopause-symptoms-ebook","https:\u002F\u002Fbywinona.com\u002Fultimate-guide-for-menopause-symptoms",{"source":83,"target":84,"updated":23,"redirectType":8},"bywinona.com\u002Fbf-new-patient","https:\u002F\u002Fbywinona.com\u002Fblack-friday?utm_source=facebook_group&utm_content=post-link",{"source":86,"target":87,"updated":12,"redirectType":8},"bywinona.com\u002Fmenopause-symptoms\u002Ftwitter","https:\u002F\u002Fbywinona.com\u002Fjournal\u002Fmenopause-symptoms?utm_source=twitter&utm_medium=social",{"source":89,"target":90,"updated":91,"redirectType":8},"bywinona.com\u002Fwebinar","https:\u002F\u002Fbywinona.com\u002Fliveqa","1775567855004",{"source":93,"target":41,"updated":27,"redirectType":8},"bywinona.com\u002Freviews",{"source":95,"target":96,"updated":97,"redirectType":8},"bywinona.com\u002Fdhea-therapy","https:\u002F\u002Fbywinona.com\u002Fproduct\u002Fdhea","1775567855010",{"source":99,"target":71,"updated":27,"redirectType":8},"bywinona.com\u002Fpost-quiz-not-in-menopause",{"source":101,"target":102,"updated":16,"redirectType":8},"bywinona.com\u002Ftreatments-spotify","https:\u002F\u002Fbywinona.com\u002Ftreatments?utm_source=spotify&utm_medium=social",{"source":104,"target":105,"updated":65,"redirectType":8},"bywinona.com\u002Frw25","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=REBELLIOUSWELLNESS25",{"source":107,"target":108,"updated":65,"redirectType":8},"bywinona.com\u002Ftelehealth-informed-consent","https:\u002F\u002Fbywinona.com\u002Ftelehealth-consent",{"source":110,"target":71,"updated":12,"redirectType":8},"bywinona.com\u002Fam-i-in-menopause-quiz-results",{"source":112,"target":57,"updated":97,"redirectType":8},"bywinona.com\u002Fwinonawomen",{"source":114,"target":115,"updated":38,"redirectType":8},"bywinona.com\u002Feligibility","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?utm_source=eligiblity-redirect",{"source":117,"target":118,"updated":7,"redirectType":8},"bywinona.com\u002Ftreatmentstwitter","https:\u002F\u002Fbywinona.com\u002Ftreatments?utm_source=twitter&utm_medium=social",{"source":120,"target":121,"updated":65,"redirectType":8},"bywinona.com\u002Fwebinar-secret-sale","https:\u002F\u002Fbywinona.com\u002F",{"source":123,"target":124,"updated":12,"redirectType":8},"bywinona.com\u002Fkathycote","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=KATHYCOTE",{"source":126,"target":121,"updated":38,"redirectType":8},"bywinona.com\u002Fblack-friday-existing-user",{"source":128,"target":129,"updated":91,"redirectType":8},"bywinona.com\u002Fproduct\u002Fblossom","https:\u002F\u002Fbywinona.com\u002Fproduct\u002Fsildenafil-arousal-cream",{"source":131,"target":71,"updated":91,"redirectType":8},"bywinona.com\u002Fpost-menopause-quiz-results",{"source":133,"target":134,"updated":27,"redirectType":8},"bywinona.com\u002Fdoctor","https:\u002F\u002Fapp.bywinona.com\u002Fmessages\u002Fdoctor?utm_content=follow-up-letter",{"source":136,"target":137,"updated":12,"redirectType":8},"bywinona.com\u002Ftreatment-options","https:\u002F\u002Fbywinona.com\u002Ftreatments",{"source":139,"target":140,"updated":38,"redirectType":8},"bywinona.com\u002Fyoutube","https:\u002F\u002Fbywinona.com?utm_source=youtube&utm_medium=social",{"source":142,"target":143,"updated":61,"redirectType":8},"bywinona.com\u002Ftscitychic","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=TSCITYCHIC",{"source":145,"target":146,"updated":12,"redirectType":8},"bywinona.com\u002Ffearless-aging","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=FEARLESS25&utm_source=affiliate",{"source":148,"target":149,"updated":78,"redirectType":8},"bywinona.com\u002Fjourna","https:\u002F\u002Fbywinona.com\u002Fjournal",{"source":151,"target":71,"updated":23,"redirectType":8},"bywinona.com\u002Fpost-quiz-menopausev2",{"source":153,"target":154,"updated":91,"redirectType":8},"bywinona.com\u002Fadv\u002Fsymptom\u002Fcortisol","https:\u002F\u002Fbywinona.com",{"source":156,"target":71,"updated":91,"redirectType":8},"bywinona.com\u002Fmenopause-quiz-results",{"source":158,"target":159,"updated":91,"redirectType":8},"bywinona.com\u002Fxojacqui","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=XOJACQUI",{"source":161,"target":162,"updated":12,"redirectType":8},"bywinona.com\u002Fmodernmom","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=MODERNMOM&utm_source=podcast&htrafficsource=podcast&sl=modernmom",{"source":164,"target":165,"updated":61,"redirectType":8},"bywinona.com\u002Fbf2022","https:\u002F\u002Fapp.bywinona.com\u002Flogin?promocode=BLACKFRIDAY2022&utm_source=sms",{"source":167,"target":168,"updated":91,"redirectType":8},"bywinona.com\u002Fauthors\u002Fdr-kerrie-spoonmore","https:\u002F\u002Fbywinona.com\u002Fphysicians\u002Fdr-kerrie-spoonmore",{"source":170,"target":171,"updated":172,"redirectType":8},"bywinona.com\u002Fauthors\u002Fkerrie","https:\u002F\u002Fbywinona.com\u002Fauthors\u002Fdr-kerrie-spoonmore","1775567855009",{"source":174,"target":71,"updated":7,"redirectType":8},"bywinona.com\u002Fpost-quiz-perimenopause",{"source":176,"target":177,"updated":78,"redirectType":8},"bywinona.com\u002Ftreatmentsyoutube","https:\u002F\u002Fbywinona.com\u002Ftreatments?utm_source=youtube&utm_medium=social",{"source":179,"target":180,"updated":61,"redirectType":8},"bywinona.com\u002Fmorbidology","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=MORBIDOLOGY&utm_source=podcast&htrafficsource=podcast&sl=morbidology",{"source":182,"target":183,"updated":38,"redirectType":8},"bywinona.com\u002Fyour-fun-sister","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=YOURFUNSISTER&utm_source=affiliate",{"source":185,"target":186,"updated":91,"redirectType":8},"bywinona.com\u002Ftreatmentsfb","https:\u002F\u002Fbywinona.com\u002Ftreatments?utm_source=fb&utm_medium=social",{"source":188,"target":189,"updated":16,"redirectType":8},"bywinona.com\u002Fgood","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=GHK30&utm_source=good-house-keeping&utm_content=magazine",{"source":191,"target":137,"updated":91,"redirectType":8},"bywinona.com\u002Ftreatment",{"source":193,"target":194,"updated":12,"redirectType":8},"bywinona.com\u002Fjournal\u002Ffriendships-health-benefits\u002Ffacebook","https:\u002F\u002Fbywinona.com\u002Fjournal\u002Fneurology-mental-health\u002Ffriendships-mental-health?utm_source=fb&utm_medium=social",{"source":196,"target":121,"updated":31,"redirectType":8},"bywinona.com\u002Fcyber-monday",{"source":198,"target":121,"updated":16,"redirectType":8},"bywinona.com\u002Fblack-friday",{"source":200,"target":201,"updated":27,"redirectType":8},"bywinona.com\u002Fsign-in","https:\u002F\u002Fapp.bywinona.com\u002Flogin?sl=sms&utm_source=sms&utm_campaign=abandoned-onboarding&utm_content=login",{"source":203,"target":71,"updated":27,"redirectType":8},"bywinona.com\u002Fpost-quiz-menopause",{"source":205,"target":206,"updated":31,"redirectType":8},"bywinona.com\u002Flogin","https:\u002F\u002Fapp.bywinona.com\u002Flogin?utm_source=bywinona.com\u002Flogin",{"source":208,"target":209,"updated":172,"redirectType":8},"bywinona.com\u002Fsadler","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=SADLER&utm_source=podcast",{"source":211,"target":137,"updated":23,"redirectType":8},"bywinona.com\u002Fv2\u002Ftreatments",{"source":213,"target":214,"updated":23,"redirectType":8},"bywinona.com\u002Fliveqatwitter","https:\u002F\u002Fbywinona.com\u002Fliveqa?utm_source=twitter&utm_medium=social",{"source":216,"target":217,"updated":23,"redirectType":8},"bywinona.com\u002Freturn40","https:\u002F\u002Fapp.bywinona.com\u002Flogin?promocode=RETURN40&sl=sms&utm_source=sms&utm_campaign=abandoned-onboarding&utm_content=onboarding40",{"source":219,"target":220,"updated":172,"redirectType":8},"bywinona.com\u002Fauthors\u002Fdr-lee","https:\u002F\u002Fbywinona.com\u002Fauthors\u002Fdr-rebecca-lee",{"source":222,"target":121,"updated":38,"redirectType":8},"bywinona.com\u002Fcyber-monday-existing-user",{"source":224,"target":225,"updated":12,"redirectType":8},"bywinona.com\u002Fppl","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=PPL30&utm_source=people&utm_content=magazine",{"source":227,"target":228,"updated":7,"redirectType":8},"bywinona.com\u002Fauthors\u002Fnancy-belcher","https:\u002F\u002Fbywinona.com\u002Fphysicians\u002Fnancy-belcher",{"source":230,"target":231,"updated":12,"redirectType":8},"https:\u002F\u002Fapp.bywinona.com\u002Feligibility\u002Flinkedin","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?utm_source=linkedin&utm_medium=social",{"source":233,"target":234,"updated":27,"redirectType":8},"bywinona.com\u002Fbon","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=BON30&utm_source=bon-appetit&utm_content=magazine",{"source":236,"target":237,"updated":65,"redirectType":8},"bywinona.com\u002Fauthors\u002Fdr-michael-green","https:\u002F\u002Fbywinona.com\u002Fphysicians\u002Fdr-michael-green",{"source":239,"target":240,"updated":7,"redirectType":8},"bywinona.com\u002Fmenopause-symptoms\u002Flinkedin","https:\u002F\u002Fbywinona.com\u002Fjournal\u002Fmenopause-symptoms?utm_source=linkedin&utm_medium=social",{"source":242,"target":71,"updated":65,"redirectType":8},"bywinona.com\u002Fpost-quiz-postmenopause",{"source":244,"target":245,"updated":16,"redirectType":8},"bywinona.com\u002Fquiz","https:\u002F\u002Fbywinona.com\u002Fhealth-quiz?sl=sms&utm_source=sms&utm_campaign=abandoned-onboarding&utm_content=quiz",{"source":247,"target":248,"updated":27,"redirectType":8},"bywinona.com\u002Fblossom","https:\u002F\u002Fbywinona.com\u002Fproduct\u002Fblossom",{"source":250,"target":251,"updated":172,"redirectType":8},"bywinona.com\u002Fliveqafb","https:\u002F\u002Fbywinona.com\u002Fliveqa?utm_source=fb&utm_medium=social",{"source":253,"target":254,"updated":78,"redirectType":8},"bywinona.com\u002Fjournalyoutube","https:\u002F\u002Fbywinona.com\u002Fjournal?utm_source=youtube&utm_medium=social",{"source":256,"target":257,"updated":78,"redirectType":8},"bywinona.com\u002Fsupport","https:\u002F\u002Fapp.bywinona.com\u002Fsupport",{"source":259,"target":260,"updated":23,"redirectType":8},"bywinona.com\u002Fauthors\u002Fjohannah-gregg","https:\u002F\u002Fbywinona.com\u002Fphysicians\u002Fjohannah-gregg",{"source":262,"target":263,"updated":97,"redirectType":8},"bywinona.com\u002Freturn30","https:\u002F\u002Fapp.bywinona.com\u002Flogin?promocode=RETURN30&sl=sms&utm_source=sms&utm_campaign=abandoned-onboarding&utm_content=onboarding30",{"source":265,"target":266,"updated":78,"redirectType":8},"bywinona.com\u002Fauthors\u002Fdr-saranne-perman","https:\u002F\u002Fbywinona.com\u002Fphysicians\u002Fdr-saranne-perman",{"source":268,"target":269,"updated":172,"redirectType":8},"bywinona.com\u002Fbf-existing","https:\u002F\u002Fbywinona.com\u002Fblack-friday-existing-user?utm_source=facebook_group&utm_content=post-link",{"source":271,"target":272,"updated":78,"redirectType":8},"bywinona.com\u002Felle","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=ELLE30&utm_source=elle&utm_content=magazine",{"source":274,"target":275,"updated":78,"redirectType":8},"bywinona.com\u002Fhome","https:\u002F\u002Fbywinona.com?utm_source=\u002Fhome",{"source":277,"target":278,"updated":172,"redirectType":8},"bywinona.com\u002Fresume","https:\u002F\u002Fapp.bywinona.com\u002Flogin?sl=sms&utm_source=sms&utm_campaign=welcome-message&utm_content=login",{"source":280,"target":281,"updated":91,"redirectType":8},"bywinona.com\u002Fauthors\u002Fnancy","https:\u002F\u002Fbywinona.com\u002Fauthors\u002Fnancy-belcher",{"source":283,"target":284,"updated":27,"redirectType":8},"bywinona.com\u002Fprogesterone-therapy","https:\u002F\u002Fbywinona.com\u002Fproduct\u002Fprogesterone-body-cream",{"source":286,"target":287,"updated":78,"redirectType":8},"bywinona.com\u002Fauthors\u002Fdr-green","https:\u002F\u002Fbywinona.com\u002Fauthors\u002Fdr-michael-green",{"source":289,"target":290,"updated":38,"redirectType":8},"bywinona.com\u002Freturn20","https:\u002F\u002Fapp.bywinona.com\u002Flogin?promocode=RETURN20&sl=sms&utm_source=sms&utm_campaign=abandoned-onboarding&utm_content=onboarding20",{"source":292,"target":77,"updated":65,"redirectType":8},"bywinona.com\u002Fabout",{"source":294,"target":295,"updated":7,"redirectType":8},"bywinona.com\u002Ftreatmentslinkedin","https:\u002F\u002Fbywinona.com\u002Ftreatments?utm_source=linkedin&utm_medium=social",{"source":297,"target":298,"updated":7,"redirectType":8},"bywinona.com\u002Fbazaar","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=BZR30&utm_source=people&utm_content=magazine",{"source":300,"target":301,"updated":31,"redirectType":8},"bywinona.com\u002Fauthors\u002Fdr-brown","https:\u002F\u002Fbywinona.com\u002Fphysicians\u002Fdr-cathleen-brown",{"source":303,"target":304,"updated":23,"redirectType":8},"bywinona.com\u002Fstart-now","https:\u002F\u002Fapp.bywinona.com\u002Feligibility",{"source":306,"target":71,"updated":78,"redirectType":8},"bywinona.com\u002Fpost-quiz-perimenopausev2",{"source":308,"target":71,"updated":78,"redirectType":8},"bywinona.com\u002Fam-i-in-menopause-quiz",{"source":310,"target":311,"updated":172,"redirectType":8},"bywinona.com\u002Febook","https:\u002F\u002Fdrive.google.com\u002Ffile\u002Fd\u002F1frNlyw0MpBxstEAIQPZRQYCfqSRW76qi\u002Fview",{"source":313,"target":314,"updated":65,"redirectType":8},"bywinona.com\u002Fauthors\u002Fdr-perman","https:\u002F\u002Fbywinona.com\u002Fauthors\u002Fdr-saranne-perman",{"source":316,"target":317,"updated":7,"redirectType":8},"bywinona.com\u002Fsecret-sale","https:\u002F\u002Fbywinona.com\u002Fwebinar-secret-sale?promocode=SECRET40&utm_source=webinar&utm_content=secret-sale",{"source":319,"target":301,"updated":320,"redirectType":8},"bywinona.com\u002Fauthors\u002Fdr-cathleen-brown","1775567855013",{"source":322,"target":323,"updated":27,"redirectType":8},"bywinona.com\u002Fmessage","https:\u002F\u002Fapp.bywinona.com\u002Fmessage?sl=sms&utm_source=sms&utm_campaign=abandoned-onboarding&utm_content=message",{"source":325,"target":326,"updated":97,"redirectType":8},"bywinona.com\u002Ffaq","https:\u002F\u002Fhelp.bywinona.com\u002Fen\u002F",{"source":328,"target":329,"updated":65,"redirectType":8},"bywinona.com\u002Fproduct\u002Festriol-cream-with-tretinoin-bfcm","https:\u002F\u002Fbywinona.com\u002Fproduct\u002Festriol-cream-with-tretinoin",{"source":331,"target":332,"updated":38,"redirectType":8},"bywinona.com\u002Fproduct\u002Fprogesterone-capsules","https:\u002F\u002Fbywinona.com\u002Fproduct\u002Fprogesterone-capsule",{"source":334,"target":335,"updated":97,"redirectType":8},"bywinona.com\u002Fnicole","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?promocode=NICOLE20",{"source":337,"target":154,"updated":31,"redirectType":8},"bywinona.com\u002Fv2",{"source":339,"target":340,"updated":23,"redirectType":8},"bywinona.com\u002Festrogen-therapy","https:\u002F\u002Fbywinona.com\u002Fproduct\u002Festrogen-body-cream",{"source":342,"target":343,"updated":65,"redirectType":8},"bywinona.com\u002Fcall","https:\u002F\u002Fcalendly.com\u002Fwinona-patient-care\u002Fmeet-winona-call?utm_source=sms",{"source":345,"target":346,"updated":23,"redirectType":8},"bywinona.com\u002Fauthors\u002Fdr-rebecca-lee","https:\u002F\u002Fbywinona.com\u002Fphysicians\u002Fdr-rebecca-lee",{"source":348,"target":71,"updated":31,"redirectType":8},"bywinona.com\u002Fpost-quiz-postmenopausev2",{"source":350,"target":351,"updated":91,"redirectType":8},"bywinona.com\u002Fbfblossom22","https:\u002F\u002Fapp.bywinona.com\u002Flogin?promocode=BFBLOSSOM40",{"source":353,"target":354,"updated":23,"redirectType":8},"https:\u002F\u002Fapp.bywinona.com\u002Feligibility\u002Ffacebook","https:\u002F\u002Fapp.bywinona.com\u002Feligibility?utm_source=fb&utm_medium=social",{"source":356,"target":357,"updated":23,"redirectType":8},"bywinona.com\u002Fcommunity","https:\u002F\u002Fsso.auth.bywinona.com\u002Fsign-up?utm_source=\u002Fcommunity",{"source":359,"target":360,"updated":27,"redirectType":8},"bywinona.com\u002Fcm2022","https:\u002F\u002Fapp.bywinona.com\u002Flogin?promocode=CYBERMONDAY2022&utm_source=sms",{"source":362,"target":121,"updated":65,"redirectType":8},"bywinona.com\u002Fhot-flash-event",{"source":364,"target":365,"updated":91,"redirectType":8},"bywinona.com\u002Fcorporate","https:\u002F\u002Fbywinona.com\u002Femployers?utm_source=\u002Fcorporate",{"source":367,"target":368,"updated":12,"redirectType":8},"bywinona.com\u002Ftrustpilot","https:\u002F\u002Fwww.trustpilot.com\u002Freview\u002Fbywinona.com?sl=sms&utm_source=sms&utm_campaign=abandoned-onboarding&utm_content=trustpilot",{"source":370,"target":326,"updated":12,"redirectType":8},"bywinona.com\u002Fjournal\u002Ffaq-winona",{"source":372,"target":373,"updated":38,"redirectType":8},"bywinona.com\u002Flive","https:\u002F\u002Fbywinona.com\u002Fwebinar?sl=sms&utm_source=sms&utm_campaign=welcome-message&utm_content=webinars",{"journalCollection":375},{"items":376},[377],{"__typename":378,"sys":379,"bottomLine":383,"referencesList":442,"title":694,"slug":695,"slugV2":696,"thumbnail":697,"categoryV2":700,"seo":704,"tagsCollection":721,"author":753,"physicianReviewersCollection":758,"faqs":769,"content":825},"Journal",{"id":380,"publishedAt":381,"firstPublishedAt":382},"2aY8wpl3fNnFGcxHye616f","2026-03-26T15:26:27.534Z","2025-10-01T05:29:29.116Z",{"json":384},{"nodeType":385,"data":386,"content":387},"document",{},[388,435],{"nodeType":389,"data":390,"content":391},"unordered-list",{},[392,405,415,425],{"nodeType":393,"data":394,"content":395},"list-item",{},[396],{"nodeType":397,"data":398,"content":399},"paragraph",{},[400],{"nodeType":401,"value":402,"marks":403,"data":404},"text","Combined hormone replacement therapy (HRT) with estrogen and progesterone serves two important purposes: relief from menopausal symptoms (hot flashes, mood changes, sleep disturbances, etc.) and endometrial protection.",[],{},{"nodeType":393,"data":406,"content":407},{},[408],{"nodeType":397,"data":409,"content":410},{},[411],{"nodeType":401,"value":412,"marks":413,"data":414},"For women with an intact uterus, progesterone is essential for protecting the uterus from the stimulating effects of estrogen therapy. Without progesterone to counter this effect, the lining of the uterus can thicken, increasing the risk of endometrial hyperplasia and endometrial cancer.",[],{},{"nodeType":393,"data":416,"content":417},{},[418],{"nodeType":397,"data":419,"content":420},{},[421],{"nodeType":401,"value":422,"marks":423,"data":424},"Progesterone is available in a synthetic form (progestin) or a bioidentical form (oral micronized progesterone). Bioidentical progesterone is molecularly identical to the progesterone naturally produced in women’s bodies and can be administered in different doses as a capsule or body cream. ",[],{},{"nodeType":393,"data":426,"content":427},{},[428],{"nodeType":397,"data":429,"content":430},{},[431],{"nodeType":401,"value":432,"marks":433,"data":434},"In some cases, estrogen-only therapy may be recommended for women who have had a hysterectomy because there is no uterine lining to protect. HRT treatment plans are always individualized to each patient, taking into account a woman’s age, symptoms, medical history, risk factors, and personal preferences. ",[],{},{"nodeType":397,"data":436,"content":437},{},[438],{"nodeType":401,"value":439,"marks":440,"data":441},"",[],{},{"json":443},{"data":444,"content":445,"nodeType":385},{},[446,452,688],{"data":447,"content":448,"nodeType":397},{},[449],{"data":450,"marks":451,"value":439,"nodeType":401},{},[],{"data":453,"content":454,"nodeType":687},{},[455,478,499,520,541,562,583,604,625,646,666],{"data":456,"content":457,"nodeType":393},{},[458],{"data":459,"content":460,"nodeType":397},{},[461,464,475],{"data":462,"marks":463,"value":439,"nodeType":401},{},[],{"data":465,"content":467,"nodeType":474},{"uri":466},"https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fbooks\u002FNBK285446\u002F",[468],{"data":469,"marks":470,"value":473,"nodeType":401},{},[471],{"type":472},"underline","Menopausal Symptoms: Comparative Effectiveness of Therapies","hyperlink",{"data":476,"marks":477,"value":439,"nodeType":401},{},[],{"data":479,"content":480,"nodeType":393},{},[481],{"data":482,"content":483,"nodeType":397},{},[484,487,496],{"data":485,"marks":486,"value":439,"nodeType":401},{},[],{"data":488,"content":490,"nodeType":474},{"uri":489},"https:\u002F\u002Fwww.nhs.uk\u002Fmedicines\u002Fhormone-replacement-therapy-hrt\u002Ftypes-of-hormone-replacement-therapy-hrt\u002F",[491],{"data":492,"marks":493,"value":495,"nodeType":401},{},[494],{"type":472},"Types of hormone replacement therapy (HRT)",{"data":497,"marks":498,"value":439,"nodeType":401},{},[],{"data":500,"content":501,"nodeType":393},{},[502],{"data":503,"content":504,"nodeType":397},{},[505,508,517],{"data":506,"marks":507,"value":439,"nodeType":401},{},[],{"data":509,"content":511,"nodeType":474},{"uri":510},"https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS037851221500314X",[512],{"data":513,"marks":514,"value":516,"nodeType":401},{},[515],{"type":472},"17β-Estradiol and natural progesterone for menopausal hormone therapy: REPLENISH phase 3 study design of a combination capsule and evidence review",{"data":518,"marks":519,"value":439,"nodeType":401},{},[],{"data":521,"content":522,"nodeType":393},{},[523],{"data":524,"content":525,"nodeType":397},{},[526,529,538],{"data":527,"marks":528,"value":439,"nodeType":401},{},[],{"data":530,"content":532,"nodeType":474},{"uri":531},"https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS174067572030013X",[533],{"data":534,"marks":535,"value":537,"nodeType":401},{},[536],{"type":472},"Women’s reproductive system as balanced estradiol and progesterone actions—A revolutionary, paradigm-shifting concept in women’s health",{"data":539,"marks":540,"value":439,"nodeType":401},{},[],{"data":542,"content":543,"nodeType":393},{},[544],{"data":545,"content":546,"nodeType":397},{},[547,550,559],{"data":548,"marks":549,"value":439,"nodeType":401},{},[],{"data":551,"content":553,"nodeType":474},{"uri":552},"https:\u002F\u002Fwww.sciencedirect.com\u002Fscience\u002Farticle\u002Fpii\u002FS0091302220300479",[554],{"data":555,"marks":556,"value":558,"nodeType":401},{},[557],{"type":472},"Progesterone – Friend or foe?",{"data":560,"marks":561,"value":439,"nodeType":401},{},[],{"data":563,"content":564,"nodeType":393},{},[565],{"data":566,"content":567,"nodeType":397},{},[568,571,580],{"data":569,"marks":570,"value":439,"nodeType":401},{},[],{"data":572,"content":574,"nodeType":474},{"uri":573},"https:\u002F\u002Fpmc.ncbi.nlm.nih.gov\u002Farticles\u002FPMC4245250\u002F",[575],{"data":576,"marks":577,"value":579,"nodeType":401},{},[578],{"type":472},"Progesterone in Peri- and Postmenopause: A Review",{"data":581,"marks":582,"value":439,"nodeType":401},{},[],{"data":584,"content":585,"nodeType":393},{},[586],{"data":587,"content":588,"nodeType":397},{},[589,592,601],{"data":590,"marks":591,"value":439,"nodeType":401},{},[],{"data":593,"content":595,"nodeType":474},{"uri":594},"https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fbooks\u002FNBK493191\u002F",[596],{"data":597,"marks":598,"value":600,"nodeType":401},{},[599],{"type":472},"Hormone Replacement Therapy",{"data":602,"marks":603,"value":439,"nodeType":401},{},[],{"data":605,"content":606,"nodeType":393},{},[607],{"data":608,"content":609,"nodeType":397},{},[610,613,622],{"data":611,"marks":612,"value":439,"nodeType":401},{},[],{"data":614,"content":616,"nodeType":474},{"uri":615},"https:\u002F\u002Falzres.biomedcentral.com\u002Farticles\u002F10.1186\u002Fs13195-022-01121-5",[617],{"data":618,"marks":619,"value":621,"nodeType":401},{},[620],{"type":472},"Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of Alzheimer’s Disease (EPAD) cohort",{"data":623,"marks":624,"value":439,"nodeType":401},{},[],{"data":626,"content":627,"nodeType":393},{},[628],{"data":629,"content":630,"nodeType":397},{},[631,634,643],{"data":632,"marks":633,"value":439,"nodeType":401},{},[],{"data":635,"content":637,"nodeType":474},{"uri":636},"https:\u002F\u002Fwww.ncbi.nlm.nih.gov\u002Fbooks\u002FNBK560693\u002F",[638],{"data":639,"marks":640,"value":642,"nodeType":401},{},[641],{"type":472},"Endometrial Hyperplasia",{"data":644,"marks":645,"value":439,"nodeType":401},{},[],{"data":647,"content":648,"nodeType":393},{},[649],{"data":650,"content":651,"nodeType":397},{},[652,655,663],{"data":653,"marks":654,"value":439,"nodeType":401},{},[],{"data":656,"content":658,"nodeType":474},{"uri":657},"https:\u002F\u002Fwww.acog.org\u002Fwomens-health\u002Ffaqs\u002Fendometrial-hyperplasia",[659],{"data":660,"marks":661,"value":642,"nodeType":401},{},[662],{"type":472},{"data":664,"marks":665,"value":439,"nodeType":401},{},[],{"data":667,"content":668,"nodeType":393},{},[669],{"data":670,"content":671,"nodeType":397},{},[672,675,684],{"data":673,"marks":674,"value":439,"nodeType":401},{},[],{"data":676,"content":678,"nodeType":474},{"uri":677},"https:\u002F\u002Fpubmed.ncbi.nlm.nih.gov\u002F12117397\u002F",[679],{"data":680,"marks":681,"value":683,"nodeType":401},{},[682],{"type":472},"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial",{"data":685,"marks":686,"value":439,"nodeType":401},{},[],"ordered-list",{"data":689,"content":690,"nodeType":397},{},[691],{"data":692,"marks":693,"value":439,"nodeType":401},{},[],"Is Progesterone Essential When Taking Estrogen?","progesterone-when-taking-estrogen","progesterone-with-estrogen",{"url":698,"title":699,"description":699},"https:\u002F\u002Fimages.ctfassets.net\u002Flyqt8dkk29ch\u002F2yp2AcIGSB9OchpyosFhqM\u002F8bdde9589bcb2d9249be1a0463683195\u002Fprogesterone_and_estrogen.webp","progesterone and estrogen",{"title":701,"pageTitle":702,"slug":703},"Menopause Treatments","Understanding Menopause Treatments","treatments",{"metaTitle":694,"metaDescription":705,"metaKeywords":706,"jsonLd":707},"Taking estrogen and progesterone together? Understand the benefits, risks, and who it's right for. Expert insights on hormone therapy for menopause relief.",null,{"@context":708,"@type":709,"mainEntity":710},"https:\u002F\u002Fschema.org","FAQPage",[711,717],{"@type":712,"name":713,"acceptedAnswer":714},"Question","When is estrogen-only HRT recommended?",{"@type":715,"text":716},"Answer","Estrogen-only HRT is appropriate for individuals who have had a hysterectomy, and for some individuals using localized vaginal estrogen under medical guidance.",{"@type":712,"name":718,"acceptedAnswer":719},"Can estrogen alone help with perimenopause symptoms?",{"@type":715,"text":720},"Estrogen is the primary hormone in HRT and can relieve menopause-related symptoms and irregular periods during perimenopause. A full assessment is advised to ensure correct and safe treatment.",{"items":722},[723,729,735,741,747],{"sys":724,"title":726,"pageTitle":727,"slug":728},{"id":725},"7nlD8ko6PfNfHW8drgZxpJ","Estrogen","Estrogen Therapy for Menopause","estrogen",{"sys":730,"title":732,"pageTitle":733,"slug":734},{"id":731},"43oKu242SU6lJU1Fo3pGFI","Progesterone","Progesterone Therapy for Menopause","progesterone",{"sys":736,"title":738,"pageTitle":739,"slug":740},{"id":737},"4iTKLe3v2XahRwbkrdz9zq","HRT","HRT for Menopause","hrt",{"sys":742,"title":744,"pageTitle":745,"slug":746},{"id":743},"R7QSC0L98kqP71d5Kgfye","Uterine Fibroids","Uterine Fibroids & Menopause","uterine-fibroids",{"sys":748,"title":750,"pageTitle":751,"slug":752},{"id":749},"3RIjyUtkDOdFXVsPsAxVUR","Prevention","Preventive Health for Menopause","prevention",{"name":754,"slug":755,"image":756},"Hailey Kean","hailey-kean",{"url":757,"title":754,"description":754},"https:\u002F\u002Fimages.ctfassets.net\u002Flyqt8dkk29ch\u002F7FELdFGur2gg8KrYgHBynT\u002Fb3737e8a233f73c05d3d0ba158370a95\u002FHCKEAN_â___profile_photo.PNG",{"items":759},[760],{"sys":761,"slug":763,"name":764,"credentials":765,"image":766},{"id":762},"4jGcMm0HxGOOH60p06Hc1N","dr-cathleen-brown","Cathleen M. Brown","DO",{"url":767,"title":768},"https:\u002F\u002Fimages.ctfassets.net\u002Flyqt8dkk29ch\u002F4MvdPa8hpak2Fhi81DvbJ2\u002F1a01eb578ccfc9497afd1297a698ccda\u002FMask_group.png","Dr. Cathleen Brown",{"symptomName":706,"pageForV2":696,"name":770,"itemsCollection":771},"Frequently Asked Questions About Combination HRT",{"items":772},[773,814],{"content":774,"entryTitle":713,"title":713},{"json":775},{"nodeType":385,"data":776,"content":777},{},[778,785,808],{"nodeType":397,"data":779,"content":780},{},[781],{"nodeType":401,"value":782,"marks":783,"data":784},"Estrogen-only HRT is appropriate for the following:",[],{},{"nodeType":389,"data":786,"content":787},{},[788,798],{"nodeType":393,"data":789,"content":790},{},[791],{"nodeType":397,"data":792,"content":793},{},[794],{"nodeType":401,"value":795,"marks":796,"data":797},"Individuals who’ve had a hysterectomy",[],{},{"nodeType":393,"data":799,"content":800},{},[801],{"nodeType":397,"data":802,"content":803},{},[804],{"nodeType":401,"value":805,"marks":806,"data":807},"Some individuals using localized vaginal estrogen under medical guidance",[],{},{"nodeType":397,"data":809,"content":810},{},[811],{"nodeType":401,"value":439,"marks":812,"data":813},[],{},{"content":815,"entryTitle":718,"title":718},{"json":816},{"nodeType":385,"data":817,"content":818},{},[819],{"nodeType":397,"data":820,"content":821},{},[822],{"nodeType":401,"value":720,"marks":823,"data":824},[],{},{"json":826,"links":2605},{"data":827,"content":828,"nodeType":385},{},[829,850,869,888,895,904,910,918,965,972,1025,1032,1038,1045,1064,1071,1114,1132,1138,1145,1586,1638,1644,1651,1669,1677,1717,1724,1787,1794,1812,1836,1844,1850,1857,1864,1871,1924,1931,1949,1956,1963,2009,2016,2022,2029,2036,2043,2061,2144,2151,2158,2165,2205,2258,2265,2271,2278,2320,2353,2360,2366,2372,2379,2386,2434,2441,2448,2455,2462,2469,2478,2485,2492,2525,2532,2538,2544,2551,2558,2565,2572,2578,2585],{"data":830,"content":831,"nodeType":397},{},[832,836,846],{"data":833,"marks":834,"value":835,"nodeType":401},{},[],"Roughly 85% of women experience hot flashes or sleep disturbances during hormonal transitions, yet many are unsure which therapy option is right for them. One of the most common questions asked is whether progesterone is needed when taking estrogen for menopause symptoms.",{"data":837,"content":838,"nodeType":474},{"uri":466},[839],{"data":840,"marks":841,"value":845,"nodeType":401},{},[842,844],{"type":843},"superscript",{"type":472},"(1)",{"data":847,"marks":848,"value":849,"nodeType":401},{},[]," ",{"data":851,"content":852,"nodeType":397},{},[853,857,866],{"data":854,"marks":855,"value":856,"nodeType":401},{},[],"The short answer: If a woman still has her uterus, progesterone is generally necessary to protect it. But why?",{"data":858,"content":859,"nodeType":474},{"uri":489},[860],{"data":861,"marks":862,"value":865,"nodeType":401},{},[863,864],{"type":843},{"type":472},"(2)",{"data":867,"marks":868,"value":439,"nodeType":401},{},[],{"data":870,"content":871,"nodeType":397},{},[872,876,885],{"data":873,"marks":874,"value":875,"nodeType":401},{},[],"The answer lies in how estrogen and progesterone interact with the endometrium, or uterine lining. While estrogen is highly effective at relieving menopause-related symptoms, it also stimulates the growth of the uterine lining. Without progesterone to counter this effect, the growth can become excessive and lead to serious complications.",{"data":877,"content":878,"nodeType":474},{"uri":510},[879],{"data":880,"marks":881,"value":884,"nodeType":401},{},[882,883],{"type":843},{"type":472},"(3)",{"data":886,"marks":887,"value":439,"nodeType":401},{},[],{"data":889,"content":890,"nodeType":397},{},[891],{"data":892,"marks":893,"value":894,"nodeType":401},{},[],"This article covers how each hormone works, the benefits and risks of combined hormone replacement therapy, and practical considerations for starting treatment. While risks do exist, they’re not guaranteed and can often be managed with personalized care from a menopause-trained provider.",{"data":896,"content":902,"nodeType":903},{"target":897},{"sys":898},{"id":899,"type":900,"linkType":901},"44Ltj26qgnO6tmiehOfd7A","Link","Entry",[],"embedded-entry-block",{"data":905,"content":906,"nodeType":397},{},[907],{"data":908,"marks":909,"value":439,"nodeType":401},{},[],{"data":911,"content":912,"nodeType":917},{},[913],{"data":914,"marks":915,"value":916,"nodeType":401},{},[],"Understanding Estrogen's Role in the Body","heading-2",{"data":919,"content":920,"nodeType":397},{},[921,925,931,935,940,944,949,953,962],{"data":922,"marks":923,"value":924,"nodeType":401},{},[],"Estrogen is a group of hormones that includes ",{"data":926,"marks":927,"value":930,"nodeType":401},{},[928],{"type":929},"italic","estradiol",{"data":932,"marks":933,"value":934,"nodeType":401},{},[],", ",{"data":936,"marks":937,"value":939,"nodeType":401},{},[938],{"type":929},"estrone",{"data":941,"marks":942,"value":943,"nodeType":401},{},[],", and ",{"data":945,"marks":946,"value":948,"nodeType":401},{},[947],{"type":929},"estriol",{"data":950,"marks":951,"value":952,"nodeType":401},{},[],". Estradiol is the most potent form and is typically used in hormone replacement therapy (HRT).",{"data":954,"content":955,"nodeType":474},{"uri":531},[956],{"data":957,"marks":958,"value":961,"nodeType":401},{},[959,960],{"type":843},{"type":472},"(4)",{"data":963,"marks":964,"value":439,"nodeType":401},{},[],{"data":966,"content":967,"nodeType":397},{},[968],{"data":969,"marks":970,"value":971,"nodeType":401},{},[],"Estrogen's main functions include the following:",{"data":973,"content":974,"nodeType":389},{},[975,985,995,1005,1015],{"data":976,"content":977,"nodeType":393},{},[978],{"data":979,"content":980,"nodeType":397},{},[981],{"data":982,"marks":983,"value":984,"nodeType":401},{},[],"Supporting the development of breasts and reproductive organs",{"data":986,"content":987,"nodeType":393},{},[988],{"data":989,"content":990,"nodeType":397},{},[991],{"data":992,"marks":993,"value":994,"nodeType":401},{},[],"Regulating the menstrual cycle by thickening the endometrium",{"data":996,"content":997,"nodeType":393},{},[998],{"data":999,"content":1000,"nodeType":397},{},[1001],{"data":1002,"marks":1003,"value":1004,"nodeType":401},{},[],"Maintaining bone density",{"data":1006,"content":1007,"nodeType":393},{},[1008],{"data":1009,"content":1010,"nodeType":397},{},[1011],{"data":1012,"marks":1013,"value":1014,"nodeType":401},{},[],"Supporting cardiovascular and brain health",{"data":1016,"content":1017,"nodeType":393},{},[1018],{"data":1019,"content":1020,"nodeType":397},{},[1021],{"data":1022,"marks":1023,"value":1024,"nodeType":401},{},[],"Enhancing skin elasticity and hydration",{"data":1026,"content":1027,"nodeType":397},{},[1028],{"data":1029,"marks":1030,"value":1031,"nodeType":401},{},[],"When estrogen levels decline during menopause, these functions can be disrupted, leading to unwanted symptoms and an increased risk of osteoporosis.",{"data":1033,"content":1034,"nodeType":397},{},[1035],{"data":1036,"marks":1037,"value":439,"nodeType":401},{},[],{"data":1039,"content":1040,"nodeType":917},{},[1041],{"data":1042,"marks":1043,"value":1044,"nodeType":401},{},[],"Understanding Progesterone: The Balancing Hormone",{"data":1046,"content":1047,"nodeType":397},{},[1048,1052,1061],{"data":1049,"marks":1050,"value":1051,"nodeType":401},{},[],"Progesterone is a hormone primarily produced by the ovaries after ovulation. It plays a vital role in reproductive health and hormone balance.",{"data":1053,"content":1054,"nodeType":474},{"uri":552},[1055],{"data":1056,"marks":1057,"value":1060,"nodeType":401},{},[1058,1059],{"type":843},{"type":472},"(5)",{"data":1062,"marks":1063,"value":439,"nodeType":401},{},[],{"data":1065,"content":1066,"nodeType":397},{},[1067],{"data":1068,"marks":1069,"value":1070,"nodeType":401},{},[],"The key functions of progesterone are the following:",{"data":1072,"content":1073,"nodeType":389},{},[1074,1084,1094,1104],{"data":1075,"content":1076,"nodeType":393},{},[1077],{"data":1078,"content":1079,"nodeType":397},{},[1080],{"data":1081,"marks":1082,"value":1083,"nodeType":401},{},[],"Preparing the endometrium for implantation during the menstrual cycle",{"data":1085,"content":1086,"nodeType":393},{},[1087],{"data":1088,"content":1089,"nodeType":397},{},[1090],{"data":1091,"marks":1092,"value":1093,"nodeType":401},{},[],"Maintaining the early stages of pregnancy",{"data":1095,"content":1096,"nodeType":393},{},[1097],{"data":1098,"content":1099,"nodeType":397},{},[1100],{"data":1101,"marks":1102,"value":1103,"nodeType":401},{},[],"Countering estrogen's effects on the endometrium by limiting the thickening of the endometrial lining",{"data":1105,"content":1106,"nodeType":393},{},[1107],{"data":1108,"content":1109,"nodeType":397},{},[1110],{"data":1111,"marks":1112,"value":1113,"nodeType":401},{},[],"Helping with sleep and mood regulation",{"data":1115,"content":1116,"nodeType":397},{},[1117,1121,1129],{"data":1118,"marks":1119,"value":1120,"nodeType":401},{},[],"Sources of progesterone include the ovaries (after ovulation), the adrenals, and the placenta during pregnancy. In HRT, it's important to distinguish between natural progesterone (used by Winona) and synthetic progestins, which can behave differently in the body and may carry different risk profiles.",{"data":1122,"content":1123,"nodeType":474},{"uri":552},[1124],{"data":1125,"marks":1126,"value":1060,"nodeType":401},{},[1127,1128],{"type":843},{"type":472},{"data":1130,"marks":1131,"value":439,"nodeType":401},{},[],{"data":1133,"content":1134,"nodeType":397},{},[1135],{"data":1136,"marks":1137,"value":439,"nodeType":401},{},[],{"data":1139,"content":1140,"nodeType":917},{},[1141],{"data":1142,"marks":1143,"value":1144,"nodeType":401},{},[],"Estrogen vs. Progesterone: How do they compare and interact?",{"data":1146,"content":1147,"nodeType":1585},{},[1148,1185,1219,1258,1299,1333,1367,1401,1444,1483,1517,1551],{"data":1149,"content":1150,"nodeType":1184},{},[1151,1164,1174],{"data":1152,"content":1153,"nodeType":1163},{},[1154],{"data":1155,"content":1156,"nodeType":397},{},[1157],{"data":1158,"marks":1159,"value":1162,"nodeType":401},{},[1160],{"type":1161},"bold","Category","table-cell",{"data":1165,"content":1166,"nodeType":1163},{},[1167],{"data":1168,"content":1169,"nodeType":397},{},[1170],{"data":1171,"marks":1172,"value":726,"nodeType":401},{},[1173],{"type":1161},{"data":1175,"content":1176,"nodeType":1163},{},[1177],{"data":1178,"content":1179,"nodeType":397},{},[1180],{"data":1181,"marks":1182,"value":732,"nodeType":401},{},[1183],{"type":1161},"table-row",{"data":1186,"content":1187,"nodeType":1184},{},[1188,1199,1209],{"data":1189,"content":1190,"nodeType":1163},{},[1191],{"data":1192,"content":1193,"nodeType":397},{},[1194],{"data":1195,"marks":1196,"value":1198,"nodeType":401},{},[1197],{"type":1161},"Primary Function",{"data":1200,"content":1201,"nodeType":1163},{},[1202],{"data":1203,"content":1204,"nodeType":397},{},[1205],{"data":1206,"marks":1207,"value":1208,"nodeType":401},{},[],"Develops and maintains female reproductive tissues and secondary sex characteristics",{"data":1210,"content":1211,"nodeType":1163},{},[1212],{"data":1213,"content":1214,"nodeType":397},{},[1215],{"data":1216,"marks":1217,"value":1218,"nodeType":401},{},[],"Prepares the uterus for implantation and maintains early pregnancy",{"data":1220,"content":1221,"nodeType":1184},{},[1222,1233,1243],{"data":1223,"content":1224,"nodeType":1163},{},[1225],{"data":1226,"content":1227,"nodeType":397},{},[1228],{"data":1229,"marks":1230,"value":1232,"nodeType":401},{},[1231],{"type":1161},"Produced by",{"data":1234,"content":1235,"nodeType":1163},{},[1236],{"data":1237,"content":1238,"nodeType":397},{},[1239],{"data":1240,"marks":1241,"value":1242,"nodeType":401},{},[],"Ovaries (mainly), adrenal glands, and fat tissue",{"data":1244,"content":1245,"nodeType":1163},{},[1246],{"data":1247,"content":1248,"nodeType":397},{},[1249,1254],{"data":1250,"marks":1251,"value":1253,"nodeType":401},{},[1252],{"type":929},"Corpus luteum",{"data":1255,"marks":1256,"value":1257,"nodeType":401},{},[]," (in ovaries), placenta during pregnancy, and adrenal glands",{"data":1259,"content":1260,"nodeType":1184},{},[1261,1272,1282],{"data":1262,"content":1263,"nodeType":1163},{},[1264],{"data":1265,"content":1266,"nodeType":397},{},[1267],{"data":1268,"marks":1269,"value":1271,"nodeType":401},{},[1270],{"type":1161},"Phases of the Menstrual Cycle",{"data":1273,"content":1274,"nodeType":1163},{},[1275],{"data":1276,"content":1277,"nodeType":397},{},[1278],{"data":1279,"marks":1280,"value":1281,"nodeType":401},{},[],"Peaks during the follicular phase (first part of the menstrual cycle)",{"data":1283,"content":1284,"nodeType":1163},{},[1285,1292],{"data":1286,"content":1287,"nodeType":397},{},[1288],{"data":1289,"marks":1290,"value":1291,"nodeType":401},{},[],"Peaks during the luteal phase",{"data":1293,"content":1294,"nodeType":397},{},[1295],{"data":1296,"marks":1297,"value":1298,"nodeType":401},{},[],"(second half of the menstrual cycle)",{"data":1300,"content":1301,"nodeType":1184},{},[1302,1313,1323],{"data":1303,"content":1304,"nodeType":1163},{},[1305],{"data":1306,"content":1307,"nodeType":397},{},[1308],{"data":1309,"marks":1310,"value":1312,"nodeType":401},{},[1311],{"type":1161},"Effects on the Uterus",{"data":1314,"content":1315,"nodeType":1163},{},[1316],{"data":1317,"content":1318,"nodeType":397},{},[1319],{"data":1320,"marks":1321,"value":1322,"nodeType":401},{},[],"Stimulates endometrial thickening",{"data":1324,"content":1325,"nodeType":1163},{},[1326],{"data":1327,"content":1328,"nodeType":397},{},[1329],{"data":1330,"marks":1331,"value":1332,"nodeType":401},{},[],"Stabilizes the endometrium for implantation",{"data":1334,"content":1335,"nodeType":1184},{},[1336,1347,1357],{"data":1337,"content":1338,"nodeType":1163},{},[1339],{"data":1340,"content":1341,"nodeType":397},{},[1342],{"data":1343,"marks":1344,"value":1346,"nodeType":401},{},[1345],{"type":1161},"Effects on Cervical Mucus",{"data":1348,"content":1349,"nodeType":1163},{},[1350],{"data":1351,"content":1352,"nodeType":397},{},[1353],{"data":1354,"marks":1355,"value":1356,"nodeType":401},{},[],"Thins mucus, making it more receptive to sperm",{"data":1358,"content":1359,"nodeType":1163},{},[1360],{"data":1361,"content":1362,"nodeType":397},{},[1363],{"data":1364,"marks":1365,"value":1366,"nodeType":401},{},[],"Thickens mucus, making it less penetrable",{"data":1368,"content":1369,"nodeType":1184},{},[1370,1381,1391],{"data":1371,"content":1372,"nodeType":1163},{},[1373],{"data":1374,"content":1375,"nodeType":397},{},[1376],{"data":1377,"marks":1378,"value":1380,"nodeType":401},{},[1379],{"type":1161},"During Perimenopause",{"data":1382,"content":1383,"nodeType":1163},{},[1384],{"data":1385,"content":1386,"nodeType":397},{},[1387],{"data":1388,"marks":1389,"value":1390,"nodeType":401},{},[],"Levels fluctuate irregularly, which may lead to noticeable symptoms",{"data":1392,"content":1393,"nodeType":1163},{},[1394],{"data":1395,"content":1396,"nodeType":397},{},[1397],{"data":1398,"marks":1399,"value":1400,"nodeType":401},{},[],"Levels often decline more sharply, leading to unopposed estrogen effects",{"data":1402,"content":1403,"nodeType":1184},{},[1404,1415,1425],{"data":1405,"content":1406,"nodeType":1163},{},[1407],{"data":1408,"content":1409,"nodeType":397},{},[1410],{"data":1411,"marks":1412,"value":1414,"nodeType":401},{},[1413],{"type":1161},"Postmenopause",{"data":1416,"content":1417,"nodeType":1163},{},[1418],{"data":1419,"content":1420,"nodeType":397},{},[1421],{"data":1422,"marks":1423,"value":1424,"nodeType":401},{},[],"Levels decline gradually",{"data":1426,"content":1427,"nodeType":1163},{},[1428],{"data":1429,"content":1430,"nodeType":397},{},[1431,1435,1440],{"data":1432,"marks":1433,"value":1434,"nodeType":401},{},[],"Drops significantly; deficiency ",{"data":1436,"marks":1437,"value":1439,"nodeType":401},{},[1438],{"type":929},"may",{"data":1441,"marks":1442,"value":1443,"nodeType":401},{},[]," increase sensitivity to estrogen effects",{"data":1445,"content":1446,"nodeType":1184},{},[1447,1458,1468],{"data":1448,"content":1449,"nodeType":1163},{},[1450],{"data":1451,"content":1452,"nodeType":397},{},[1453],{"data":1454,"marks":1455,"value":1457,"nodeType":401},{},[1456],{"type":1161},"HRT (Hormone Replacement Therapy)",{"data":1459,"content":1460,"nodeType":1163},{},[1461],{"data":1462,"content":1463,"nodeType":397},{},[1464],{"data":1465,"marks":1466,"value":1467,"nodeType":401},{},[],"Often used in both estrogen-only and combined formulations",{"data":1469,"content":1470,"nodeType":1163},{},[1471],{"data":1472,"content":1473,"nodeType":397},{},[1474,1478],{"data":1475,"marks":1476,"value":1477,"nodeType":401},{},[],"Used in combination with estrogen to protect the uterus from ",{"data":1479,"marks":1480,"value":1482,"nodeType":401},{},[1481],{"type":929},"endometrial hyperplasia",{"data":1484,"content":1485,"nodeType":1184},{},[1486,1497,1507],{"data":1487,"content":1488,"nodeType":1163},{},[1489],{"data":1490,"content":1491,"nodeType":397},{},[1492],{"data":1493,"marks":1494,"value":1496,"nodeType":401},{},[1495],{"type":1161},"Cancer Risk Considerations",{"data":1498,"content":1499,"nodeType":1163},{},[1500],{"data":1501,"content":1502,"nodeType":397},{},[1503],{"data":1504,"marks":1505,"value":1506,"nodeType":401},{},[],"Unopposed estrogen increases the risk of endometrial cancer",{"data":1508,"content":1509,"nodeType":1163},{},[1510],{"data":1511,"content":1512,"nodeType":397},{},[1513],{"data":1514,"marks":1515,"value":1516,"nodeType":401},{},[],"Has a protective effect against endometrial cancer when combined with estrogen",{"data":1518,"content":1519,"nodeType":1184},{},[1520,1531,1541],{"data":1521,"content":1522,"nodeType":1163},{},[1523],{"data":1524,"content":1525,"nodeType":397},{},[1526],{"data":1527,"marks":1528,"value":1530,"nodeType":401},{},[1529],{"type":1161},"Common Forms in HRT",{"data":1532,"content":1533,"nodeType":1163},{},[1534],{"data":1535,"content":1536,"nodeType":397},{},[1537],{"data":1538,"marks":1539,"value":1540,"nodeType":401},{},[],"Estradiol (oral, transdermal, vaginal)",{"data":1542,"content":1543,"nodeType":1163},{},[1544],{"data":1545,"content":1546,"nodeType":397},{},[1547],{"data":1548,"marks":1549,"value":1550,"nodeType":401},{},[],"Micronized progesterone (oral, transdermal) and synthetic progestins (oral, vaginal)",{"data":1552,"content":1553,"nodeType":1184},{},[1554,1565,1575],{"data":1555,"content":1556,"nodeType":1163},{},[1557],{"data":1558,"content":1559,"nodeType":397},{},[1560],{"data":1561,"marks":1562,"value":1564,"nodeType":401},{},[1563],{"type":1161},"Interaction Summary",{"data":1566,"content":1567,"nodeType":1163},{},[1568],{"data":1569,"content":1570,"nodeType":397},{},[1571],{"data":1572,"marks":1573,"value":1574,"nodeType":401},{},[],"Stimulates tissue growth and reproductive readiness",{"data":1576,"content":1577,"nodeType":1163},{},[1578],{"data":1579,"content":1580,"nodeType":397},{},[1581],{"data":1582,"marks":1583,"value":1584,"nodeType":401},{},[],"Balances estrogen's effects, stabilizes tissues, and supports implantation","table",{"data":1587,"content":1588,"nodeType":397},{},[1589,1593,1601,1604,1612,1615,1623,1626,1635],{"data":1590,"marks":1591,"value":1592,"nodeType":401},{},[],"Together, estrogen and progesterone work in rhythm throughout the reproductive cycle and can be used in combination during menopause to mimic this natural balance.",{"data":1594,"content":1595,"nodeType":474},{"uri":489},[1596],{"data":1597,"marks":1598,"value":865,"nodeType":401},{},[1599,1600],{"type":843},{"type":472},{"data":1602,"marks":1603,"value":439,"nodeType":401},{},[],{"data":1605,"content":1606,"nodeType":474},{"uri":531},[1607],{"data":1608,"marks":1609,"value":961,"nodeType":401},{},[1610,1611],{"type":843},{"type":472},{"data":1613,"marks":1614,"value":439,"nodeType":401},{},[],{"data":1616,"content":1617,"nodeType":474},{"uri":552},[1618],{"data":1619,"marks":1620,"value":1060,"nodeType":401},{},[1621,1622],{"type":843},{"type":472},{"data":1624,"marks":1625,"value":439,"nodeType":401},{},[],{"data":1627,"content":1628,"nodeType":474},{"uri":573},[1629],{"data":1630,"marks":1631,"value":1634,"nodeType":401},{},[1632,1633],{"type":843},{"type":472},"(6)",{"data":1636,"marks":1637,"value":439,"nodeType":401},{},[],{"data":1639,"content":1640,"nodeType":397},{},[1641],{"data":1642,"marks":1643,"value":439,"nodeType":401},{},[],{"data":1645,"content":1646,"nodeType":917},{},[1647],{"data":1648,"marks":1649,"value":1650,"nodeType":401},{},[],"The Crucial Question: Do women need progesterone with estrogen?",{"data":1652,"content":1653,"nodeType":397},{},[1654,1658,1666],{"data":1655,"marks":1656,"value":1657,"nodeType":401},{},[],"For most people who have not had a hysterectomy, the answer is yes. Progesterone is not just a tag-along; it has a crucial role in making estrogen therapy safe for the uterus.",{"data":1659,"content":1660,"nodeType":474},{"uri":489},[1661],{"data":1662,"marks":1663,"value":865,"nodeType":401},{},[1664,1665],{"type":843},{"type":472},{"data":1667,"marks":1668,"value":439,"nodeType":401},{},[],{"data":1670,"content":1671,"nodeType":1676},{},[1672],{"data":1673,"marks":1674,"value":1675,"nodeType":401},{},[],"Why? The Uterine Factor","heading-3",{"data":1678,"content":1679,"nodeType":397},{},[1680,1684,1692,1695,1703,1706,1714],{"data":1681,"marks":1682,"value":1683,"nodeType":401},{},[],"Estrogen-only HRT (unopposed estrogen) stimulates the endometrium to grow. Over time, this can lead to endometrial hyperplasia, a thickening of the lining that may progress to endometrial cancer if left unaddressed.",{"data":1685,"content":1686,"nodeType":474},{"uri":510},[1687],{"data":1688,"marks":1689,"value":884,"nodeType":401},{},[1690,1691],{"type":843},{"type":472},{"data":1693,"marks":1694,"value":439,"nodeType":401},{},[],{"data":1696,"content":1697,"nodeType":474},{"uri":531},[1698],{"data":1699,"marks":1700,"value":961,"nodeType":401},{},[1701,1702],{"type":843},{"type":472},{"data":1704,"marks":1705,"value":439,"nodeType":401},{},[],{"data":1707,"content":1708,"nodeType":474},{"uri":573},[1709],{"data":1710,"marks":1711,"value":1634,"nodeType":401},{},[1712,1713],{"type":843},{"type":472},{"data":1715,"marks":1716,"value":439,"nodeType":401},{},[],{"data":1718,"content":1719,"nodeType":1676},{},[1720],{"data":1721,"marks":1722,"value":1723,"nodeType":401},{},[],"Progesterone's Protective Role",{"data":1725,"content":1726,"nodeType":397},{},[1727,1731,1739,1742,1750,1753,1761,1764,1772,1775,1784],{"data":1728,"marks":1729,"value":1730,"nodeType":401},{},[],"Progesterone counters this effect by transforming the endometrium into a stable state, reducing the risk of abnormal growth. Depending on the treatment approach, progesterone either promotes regular shedding of the lining (cyclic therapy) or keeps it consistently thin (continuous therapy). This uterine protection is the primary reason progesterone is recommended when estrogen is prescribed to individuals with an intact uterus.",{"data":1732,"content":1733,"nodeType":474},{"uri":489},[1734],{"data":1735,"marks":1736,"value":865,"nodeType":401},{},[1737,1738],{"type":843},{"type":472},{"data":1740,"marks":1741,"value":439,"nodeType":401},{},[],{"data":1743,"content":1744,"nodeType":474},{"uri":510},[1745],{"data":1746,"marks":1747,"value":884,"nodeType":401},{},[1748,1749],{"type":843},{"type":472},{"data":1751,"marks":1752,"value":439,"nodeType":401},{},[],{"data":1754,"content":1755,"nodeType":474},{"uri":531},[1756],{"data":1757,"marks":1758,"value":961,"nodeType":401},{},[1759,1760],{"type":843},{"type":472},{"data":1762,"marks":1763,"value":439,"nodeType":401},{},[],{"data":1765,"content":1766,"nodeType":474},{"uri":573},[1767],{"data":1768,"marks":1769,"value":1634,"nodeType":401},{},[1770,1771],{"type":843},{"type":472},{"data":1773,"marks":1774,"value":439,"nodeType":401},{},[],{"data":1776,"content":1777,"nodeType":474},{"uri":594},[1778],{"data":1779,"marks":1780,"value":1783,"nodeType":401},{},[1781,1782],{"type":843},{"type":472},"(7)",{"data":1785,"marks":1786,"value":439,"nodeType":401},{},[],{"data":1788,"content":1789,"nodeType":1676},{},[1790],{"data":1791,"marks":1792,"value":1793,"nodeType":401},{},[],"Exception: Women Without a Uterus",{"data":1795,"content":1796,"nodeType":397},{},[1797,1801,1809],{"data":1798,"marks":1799,"value":1800,"nodeType":401},{},[],"For women who have had a hysterectomy, estrogen-only therapy is often appropriate. There’s no endometrial lining to protect.",{"data":1802,"content":1803,"nodeType":474},{"uri":489},[1804],{"data":1805,"marks":1806,"value":865,"nodeType":401},{},[1807,1808],{"type":843},{"type":472},{"data":1810,"marks":1811,"value":439,"nodeType":401},{},[],{"data":1813,"content":1814,"nodeType":397},{},[1815,1819,1827,1832],{"data":1816,"marks":1817,"value":1818,"nodeType":401},{},[],"However, emerging research suggests that progesterone may have additional benefits beyond just uterine protection, such as effects on mood or sleep, but these uses are still under investigation and are not yet standard.",{"data":1820,"content":1821,"nodeType":474},{"uri":531},[1822],{"data":1823,"marks":1824,"value":961,"nodeType":401},{},[1825,1826],{"type":843},{"type":472},{"data":1828,"marks":1829,"value":1831,"nodeType":401},{},[1830],{"type":843}," ",{"data":1833,"marks":1834,"value":1835,"nodeType":401},{},[],"Typically, treatment is individualized, and a menopause specialist can discuss whether progesterone should be considered for a patient post-hysterectomy.",{"data":1837,"content":1842,"nodeType":1843},{"target":1838},{"sys":1839},{"id":1840,"type":900,"linkType":1841},"1q3ne7tDZVTcTv6I6iTIeA","Asset",[],"embedded-asset-block",{"data":1845,"content":1846,"nodeType":397},{},[1847],{"data":1848,"marks":1849,"value":439,"nodeType":401},{},[],{"data":1851,"content":1852,"nodeType":917},{},[1853],{"data":1854,"marks":1855,"value":1856,"nodeType":401},{},[],"What are the benefits of taking combined HRT? ",{"data":1858,"content":1859,"nodeType":1676},{},[1860],{"data":1861,"marks":1862,"value":1863,"nodeType":401},{},[],"Symptom Relief",{"data":1865,"content":1866,"nodeType":397},{},[1867],{"data":1868,"marks":1869,"value":1870,"nodeType":401},{},[],"Estrogen is the primary hormone needed for relieving menopause symptoms and is supported by progesterone. Combined HRT is effective for treating the following symptoms:",{"data":1872,"content":1873,"nodeType":389},{},[1874,1884,1894,1904,1914],{"data":1875,"content":1876,"nodeType":393},{},[1877],{"data":1878,"content":1879,"nodeType":397},{},[1880],{"data":1881,"marks":1882,"value":1883,"nodeType":401},{},[],"Hot flashes and night sweats",{"data":1885,"content":1886,"nodeType":393},{},[1887],{"data":1888,"content":1889,"nodeType":397},{},[1890],{"data":1891,"marks":1892,"value":1893,"nodeType":401},{},[],"Vaginal dryness, irritation, and painful intercourse",{"data":1895,"content":1896,"nodeType":393},{},[1897],{"data":1898,"content":1899,"nodeType":397},{},[1900],{"data":1901,"marks":1902,"value":1903,"nodeType":401},{},[],"Sleep difficulties and mood fluctuations",{"data":1905,"content":1906,"nodeType":393},{},[1907],{"data":1908,"content":1909,"nodeType":397},{},[1910],{"data":1911,"marks":1912,"value":1913,"nodeType":401},{},[],"Brain fog",{"data":1915,"content":1916,"nodeType":393},{},[1917],{"data":1918,"content":1919,"nodeType":397},{},[1920],{"data":1921,"marks":1922,"value":1923,"nodeType":401},{},[],"Joint pain and body discomfort",{"data":1925,"content":1926,"nodeType":1676},{},[1927],{"data":1928,"marks":1929,"value":1930,"nodeType":401},{},[],"Bone Health",{"data":1932,"content":1933,"nodeType":397},{},[1934,1938,1946],{"data":1935,"marks":1936,"value":1937,"nodeType":401},{},[],"Hormones support bone strength and help reduce the risk of osteoporosis and fractures. Estrogen slows bone loss by preserving bone mineral density, while progesterone can stimulate bone-building activity by supporting osteoblast function (cells that produce the materials needed for strong bone tissue)",{"data":1939,"content":1940,"nodeType":474},{"uri":531},[1941],{"data":1942,"marks":1943,"value":961,"nodeType":401},{},[1944,1945],{"type":843},{"type":472},{"data":1947,"marks":1948,"value":439,"nodeType":401},{},[],{"data":1950,"content":1951,"nodeType":1676},{},[1952],{"data":1953,"marks":1954,"value":1955,"nodeType":401},{},[],"Other Potential Benefits",{"data":1957,"content":1958,"nodeType":397},{},[1959],{"data":1960,"marks":1961,"value":1962,"nodeType":401},{},[],"Combined HRT has been shown to have the following benefits:",{"data":1964,"content":1965,"nodeType":389},{},[1966,1976],{"data":1967,"content":1968,"nodeType":393},{},[1969],{"data":1970,"content":1971,"nodeType":397},{},[1972],{"data":1973,"marks":1974,"value":1975,"nodeType":401},{},[],"Improve skin elasticity",{"data":1977,"content":1978,"nodeType":393},{},[1979],{"data":1980,"content":1981,"nodeType":397},{},[1982,1986,1994,1997,2006],{"data":1983,"marks":1984,"value":1985,"nodeType":401},{},[],"Support brain function and memory (ongoing research)",{"data":1987,"content":1988,"nodeType":474},{"uri":552},[1989],{"data":1990,"marks":1991,"value":1060,"nodeType":401},{},[1992,1993],{"type":843},{"type":472},{"data":1995,"marks":1996,"value":439,"nodeType":401},{},[],{"data":1998,"content":1999,"nodeType":474},{"uri":615},[2000],{"data":2001,"marks":2002,"value":2005,"nodeType":401},{},[2003,2004],{"type":843},{"type":472},"(8)",{"data":2007,"marks":2008,"value":439,"nodeType":401},{},[],{"data":2010,"content":2011,"nodeType":397},{},[2012],{"data":2013,"marks":2014,"value":2015,"nodeType":401},{},[],"These effects vary by individual and should not be the sole reason to start HRT.",{"data":2017,"content":2018,"nodeType":397},{},[2019],{"data":2020,"marks":2021,"value":439,"nodeType":401},{},[],{"data":2023,"content":2024,"nodeType":917},{},[2025],{"data":2026,"marks":2027,"value":2028,"nodeType":401},{},[],"What are the risks and side effects of taking progesterone with estrogen therapy? ",{"data":2030,"content":2031,"nodeType":1676},{},[2032],{"data":2033,"marks":2034,"value":2035,"nodeType":401},{},[],"Common Side Effects",{"data":2037,"content":2038,"nodeType":397},{},[2039],{"data":2040,"marks":2041,"value":2042,"nodeType":401},{},[],"Some individuals may experience side effects when starting HRT, particularly in the early weeks of treatment. These effects are generally mild and temporary. As the body adjusts to the new hormone levels, most symptoms improve or resolve entirely.",{"data":2044,"content":2045,"nodeType":397},{},[2046,2050,2058],{"data":2047,"marks":2048,"value":2049,"nodeType":401},{},[],"Estrogen and progesterone therapy may cause these common side effects:",{"data":2051,"content":2052,"nodeType":474},{"uri":594},[2053],{"data":2054,"marks":2055,"value":1783,"nodeType":401},{},[2056,2057],{"type":843},{"type":472},{"data":2059,"marks":2060,"value":439,"nodeType":401},{},[],{"data":2062,"content":2063,"nodeType":389},{},[2064,2074,2084,2094,2104,2114,2124,2134],{"data":2065,"content":2066,"nodeType":393},{},[2067],{"data":2068,"content":2069,"nodeType":397},{},[2070],{"data":2071,"marks":2072,"value":2073,"nodeType":401},{},[],"Nausea",{"data":2075,"content":2076,"nodeType":393},{},[2077],{"data":2078,"content":2079,"nodeType":397},{},[2080],{"data":2081,"marks":2082,"value":2083,"nodeType":401},{},[],"Breast tenderness",{"data":2085,"content":2086,"nodeType":393},{},[2087],{"data":2088,"content":2089,"nodeType":397},{},[2090],{"data":2091,"marks":2092,"value":2093,"nodeType":401},{},[],"Headaches",{"data":2095,"content":2096,"nodeType":393},{},[2097],{"data":2098,"content":2099,"nodeType":397},{},[2100],{"data":2101,"marks":2102,"value":2103,"nodeType":401},{},[],"Fluid retention",{"data":2105,"content":2106,"nodeType":393},{},[2107],{"data":2108,"content":2109,"nodeType":397},{},[2110],{"data":2111,"marks":2112,"value":2113,"nodeType":401},{},[],"Bloating",{"data":2115,"content":2116,"nodeType":393},{},[2117],{"data":2118,"content":2119,"nodeType":397},{},[2120],{"data":2121,"marks":2122,"value":2123,"nodeType":401},{},[],"Mood shifts or irritability",{"data":2125,"content":2126,"nodeType":393},{},[2127],{"data":2128,"content":2129,"nodeType":397},{},[2130],{"data":2131,"marks":2132,"value":2133,"nodeType":401},{},[],"Drowsiness",{"data":2135,"content":2136,"nodeType":393},{},[2137],{"data":2138,"content":2139,"nodeType":397},{},[2140],{"data":2141,"marks":2142,"value":2143,"nodeType":401},{},[],"Irregular vaginal bleeding or spotting (especially early on)",{"data":2145,"content":2146,"nodeType":397},{},[2147],{"data":2148,"marks":2149,"value":2150,"nodeType":401},{},[],"Irregular bleeding is often temporary and linked to endometrial adjustment. In most cases, it resolves with continued HRT use or dose modification.",{"data":2152,"content":2153,"nodeType":397},{},[2154],{"data":2155,"marks":2156,"value":2157,"nodeType":401},{},[],"A board-certified physician trained in menopause care can offer guidance on managing symptoms or adjusting the treatment plan, if needed.",{"data":2159,"content":2160,"nodeType":1676},{},[2161],{"data":2162,"marks":2163,"value":2164,"nodeType":401},{},[],"Potential Risks",{"data":2166,"content":2167,"nodeType":397},{},[2168,2172,2180,2183,2191,2194,2202],{"data":2169,"marks":2170,"value":2171,"nodeType":401},{},[],"Like all medications, combined HRT comes with a few potential risks:",{"data":2173,"content":2174,"nodeType":474},{"uri":466},[2175],{"data":2176,"marks":2177,"value":845,"nodeType":401},{},[2178,2179],{"type":843},{"type":472},{"data":2181,"marks":2182,"value":439,"nodeType":401},{},[],{"data":2184,"content":2185,"nodeType":474},{"uri":531},[2186],{"data":2187,"marks":2188,"value":961,"nodeType":401},{},[2189,2190],{"type":843},{"type":472},{"data":2192,"marks":2193,"value":439,"nodeType":401},{},[],{"data":2195,"content":2196,"nodeType":474},{"uri":594},[2197],{"data":2198,"marks":2199,"value":1783,"nodeType":401},{},[2200,2201],{"type":843},{"type":472},{"data":2203,"marks":2204,"value":439,"nodeType":401},{},[],{"data":2206,"content":2207,"nodeType":389},{},[2208,2218,2228,2238,2248],{"data":2209,"content":2210,"nodeType":393},{},[2211],{"data":2212,"content":2213,"nodeType":397},{},[2214],{"data":2215,"marks":2216,"value":2217,"nodeType":401},{},[],"Blood clots or venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism",{"data":2219,"content":2220,"nodeType":393},{},[2221],{"data":2222,"content":2223,"nodeType":397},{},[2224],{"data":2225,"marks":2226,"value":2227,"nodeType":401},{},[],"Stroke, with a higher risk in older women or those with preexisting risk factors",{"data":2229,"content":2230,"nodeType":393},{},[2231],{"data":2232,"content":2233,"nodeType":397},{},[2234],{"data":2235,"marks":2236,"value":2237,"nodeType":401},{},[],"Slightly increased risk of breast cancer, especially with synthetic progestins",{"data":2239,"content":2240,"nodeType":393},{},[2241],{"data":2242,"content":2243,"nodeType":397},{},[2244],{"data":2245,"marks":2246,"value":2247,"nodeType":401},{},[],"Heart disease ",{"data":2249,"content":2250,"nodeType":393},{},[2251],{"data":2252,"content":2253,"nodeType":397},{},[2254],{"data":2255,"marks":2256,"value":2257,"nodeType":401},{},[],"Gallbladder disease",{"data":2259,"content":2260,"nodeType":397},{},[2261],{"data":2262,"marks":2263,"value":2264,"nodeType":401},{},[],"Risks are low in healthy individuals who start HRT before age 60 (or within 10 years of menopause onset). Fortunately, these risks are not certain, and some, like blood clots, can be avoided with certain lifestyle adjustments. It’s important to be aware of the potential risks, highlighting why decision-making and treatment around HRT should be tailored to individual health needs.",{"data":2266,"content":2267,"nodeType":397},{},[2268],{"data":2269,"marks":2270,"value":439,"nodeType":401},{},[],{"data":2272,"content":2273,"nodeType":917},{},[2274],{"data":2275,"marks":2276,"value":2277,"nodeType":401},{},[],"Taking Estrogen Without Progesterone",{"data":2279,"content":2280,"nodeType":397},{},[2281,2285,2293,2296,2305,2308,2317],{"data":2282,"marks":2283,"value":2284,"nodeType":401},{},[],"Those with a uterus who take systemic estrogen without progesterone increase their risk of developing any of the following:",{"data":2286,"content":2287,"nodeType":474},{"uri":573},[2288],{"data":2289,"marks":2290,"value":1634,"nodeType":401},{},[2291,2292],{"type":843},{"type":472},{"data":2294,"marks":2295,"value":439,"nodeType":401},{},[],{"data":2297,"content":2298,"nodeType":474},{"uri":636},[2299],{"data":2300,"marks":2301,"value":2304,"nodeType":401},{},[2302,2303],{"type":843},{"type":472},"(9)",{"data":2306,"marks":2307,"value":439,"nodeType":401},{},[],{"data":2309,"content":2310,"nodeType":474},{"uri":657},[2311],{"data":2312,"marks":2313,"value":2316,"nodeType":401},{},[2314,2315],{"type":843},{"type":472},"(10)",{"data":2318,"marks":2319,"value":439,"nodeType":401},{},[],{"data":2321,"content":2322,"nodeType":389},{},[2323,2333,2343],{"data":2324,"content":2325,"nodeType":393},{},[2326],{"data":2327,"content":2328,"nodeType":397},{},[2329],{"data":2330,"marks":2331,"value":2332,"nodeType":401},{},[],"Simple endometrial hyperplasia without atypia (mild uterine lining overgrowth, normal cells)",{"data":2334,"content":2335,"nodeType":393},{},[2336],{"data":2337,"content":2338,"nodeType":397},{},[2339],{"data":2340,"marks":2341,"value":2342,"nodeType":401},{},[],"Complex endometrial hyperplasia without atypia (crowded uterine lining overgrowth, normal cells)",{"data":2344,"content":2345,"nodeType":393},{},[2346],{"data":2347,"content":2348,"nodeType":397},{},[2349],{"data":2350,"marks":2351,"value":2352,"nodeType":401},{},[],"Atypical hyperplasia (abnormal uterine lining cells, carries a higher risk of becoming cancerous)",{"data":2354,"content":2355,"nodeType":397},{},[2356],{"data":2357,"marks":2358,"value":2359,"nodeType":401},{},[],"This is why unopposed estrogen is not recommended unless the patient has had a hysterectomy.",{"data":2361,"content":2365,"nodeType":903},{"target":2362},{"sys":2363},{"id":2364,"type":900,"linkType":901},"2Btzrg0Ngon4iwC6IQoFgZ",[],{"data":2367,"content":2368,"nodeType":397},{},[2369],{"data":2370,"marks":2371,"value":439,"nodeType":401},{},[],{"data":2373,"content":2374,"nodeType":917},{},[2375],{"data":2376,"marks":2377,"value":2378,"nodeType":401},{},[],"Practical Aspects of Taking Combined HRT",{"data":2380,"content":2381,"nodeType":1676},{},[2382],{"data":2383,"marks":2384,"value":2385,"nodeType":401},{},[],"Forms of Administration",{"data":2387,"content":2388,"nodeType":389},{},[2389,2404,2419],{"data":2390,"content":2391,"nodeType":393},{},[2392],{"data":2393,"content":2394,"nodeType":397},{},[2395,2400],{"data":2396,"marks":2397,"value":2399,"nodeType":401},{},[2398],{"type":1161},"Oral Tablets or Capsules:",{"data":2401,"marks":2402,"value":2403,"nodeType":401},{},[]," These are available as separate or combined forms of micronized estrogen and progesterone, including estrogen tablets and capsules containing progesterone. ",{"data":2405,"content":2406,"nodeType":393},{},[2407],{"data":2408,"content":2409,"nodeType":397},{},[2410,2415],{"data":2411,"marks":2412,"value":2414,"nodeType":401},{},[2413],{"type":1161},"Transdermal Patches:",{"data":2416,"marks":2417,"value":2418,"nodeType":401},{},[]," These patches deliver estrogen through the skin, which can help reduce clotting risk. The patch is typically prescribed along with a progesterone capsule.",{"data":2420,"content":2421,"nodeType":393},{},[2422],{"data":2423,"content":2424,"nodeType":397},{},[2425,2430],{"data":2426,"marks":2427,"value":2429,"nodeType":401},{},[2428],{"type":1161},"Topical Creams:",{"data":2431,"marks":2432,"value":2433,"nodeType":401},{},[]," These creams deliver estrogen and progesterone through the skin, bypassing the liver and often allowing lower doses. Options include separate creams or a combined estrogen-progesterone formula.",{"data":2435,"content":2436,"nodeType":1676},{},[2437],{"data":2438,"marks":2439,"value":2440,"nodeType":401},{},[],"Best Time of Day to Take Estrogen and Progesterone",{"data":2442,"content":2443,"nodeType":397},{},[2444],{"data":2445,"marks":2446,"value":726,"nodeType":401},{},[2447],{"type":1161},{"data":2449,"content":2450,"nodeType":397},{},[2451],{"data":2452,"marks":2453,"value":2454,"nodeType":401},{},[],"This is usually taken at the same time daily. Morning or evening are both fine.",{"data":2456,"content":2457,"nodeType":397},{},[2458],{"data":2459,"marks":2460,"value":732,"nodeType":401},{},[2461],{"type":1161},{"data":2463,"content":2464,"nodeType":397},{},[2465],{"data":2466,"marks":2467,"value":2468,"nodeType":401},{},[],"It’s often recommended at night due to its calming effect.",{"data":2470,"content":2471,"nodeType":397},{},[2472],{"data":2473,"marks":2474,"value":2477,"nodeType":401},{},[2475,2476],{"type":929},{"type":1161},"It’s crucial to follow individualized guidance from a provider.",{"data":2479,"content":2480,"nodeType":1676},{},[2481],{"data":2482,"marks":2483,"value":2484,"nodeType":401},{},[],"What to Expect When Starting Combined HRT",{"data":2486,"content":2487,"nodeType":397},{},[2488],{"data":2489,"marks":2490,"value":2491,"nodeType":401},{},[],"When beginning combination estrogen-progesterone therapy, it's important to keep in mind the following:",{"data":2493,"content":2494,"nodeType":389},{},[2495,2505,2515],{"data":2496,"content":2497,"nodeType":393},{},[2498],{"data":2499,"content":2500,"nodeType":397},{},[2501],{"data":2502,"marks":2503,"value":2504,"nodeType":401},{},[],"It's not uncommon for some side effects to occur as the body adjusts.",{"data":2506,"content":2507,"nodeType":393},{},[2508],{"data":2509,"content":2510,"nodeType":397},{},[2511],{"data":2512,"marks":2513,"value":2514,"nodeType":401},{},[],"Hot flashes and sleep problems can improve within a few weeks.",{"data":2516,"content":2517,"nodeType":393},{},[2518],{"data":2519,"content":2520,"nodeType":397},{},[2521],{"data":2522,"marks":2523,"value":2524,"nodeType":401},{},[],"Full benefits often appear within two to three months.",{"data":2526,"content":2527,"nodeType":397},{},[2528],{"data":2529,"marks":2530,"value":2531,"nodeType":401},{},[],"Regular follow-ups with a menopause specialist are vital to evaluate individual response, adjust dosing, and ensure long-term safety.",{"data":2533,"content":2537,"nodeType":903},{"target":2534},{"sys":2535},{"id":2536,"type":900,"linkType":901},"2ujK9BW3cpg1B68HWCGH2u",[],{"data":2539,"content":2540,"nodeType":397},{},[2541],{"data":2542,"marks":2543,"value":439,"nodeType":401},{},[],{"data":2545,"content":2546,"nodeType":917},{},[2547],{"data":2548,"marks":2549,"value":2550,"nodeType":401},{},[],"Essential Progesterone",{"data":2552,"content":2553,"nodeType":397},{},[2554],{"data":2555,"marks":2556,"value":2557,"nodeType":401},{},[],"For women with a uterus, taking estrogen with progesterone is not optional; it’s essential for safety. Progesterone protects the uterine lining from overgrowth and reduces the risk of cancer. Beyond protection, the combination can also support sleep, stabilize mood, and improve menopausal symptom relief.",{"data":2559,"content":2560,"nodeType":397},{},[2561],{"data":2562,"marks":2563,"value":2564,"nodeType":401},{},[],"HRT should always be tailored to individual health history, symptom profile, and goals. For the safest and most effective treatment, consult with a menopause-informed provider who understands the full scope of HRT options and how to personalize care.",{"data":2566,"content":2567,"nodeType":397},{},[2568],{"data":2569,"marks":2570,"value":2571,"nodeType":401},{},[],"Estrogen and progesterone work best when used together thoughtfully, and when it comes to menopause care, balance isn’t key.",{"data":2573,"content":2574,"nodeType":397},{},[2575],{"data":2576,"marks":2577,"value":439,"nodeType":401},{},[],{"data":2579,"content":2580,"nodeType":917},{},[2581],{"data":2582,"marks":2583,"value":2584,"nodeType":401},{},[],"Experiencing symptoms of hormonal imbalance? Learn more about HRT.",{"data":2586,"content":2587,"nodeType":397},{},[2588,2592,2601],{"data":2589,"marks":2590,"value":2591,"nodeType":401},{},[],"Over 35 and struggling with hormone-related symptoms? There’s no need to struggle in silence. Take this ",{"data":2593,"content":2595,"nodeType":474},{"uri":2594},"https:\u002F\u002Fbywinona.com\u002Fhealth-quiz",[2596],{"data":2597,"marks":2598,"value":2600,"nodeType":401},{},[2599],{"type":472},"brief quiz",{"data":2602,"marks":2603,"value":2604,"nodeType":401},{},[]," to see if you’re an eligible candidate for HRT. Get started with Winona to take the first step toward feeling better.",{"assets":2606,"entries":2613},{"hyperlink":2607,"block":2608},[],[2609],{"sys":2610,"url":2611,"title":2612,"description":2612},{"id":1840},"https:\u002F\u002Fimages.ctfassets.net\u002Flyqt8dkk29ch\u002F1q3ne7tDZVTcTv6I6iTIeA\u002F6a430654bf88bc9465de337b307b0aaf\u002Ftaking_progesterone_with_estrogen.webp","taking progesterone with estrogen",{"inline":2614,"block":2615},[],[2616,2628,2647],{"sys":2617,"__typename":2618,"title":2619,"slug":2620,"altText":2621,"url":2622,"desktopImage":2623,"mobileImage":2626},{"id":899},"ImageAds","HRT Ad 6","hrt-ad-6","Start your custom, science-backed menopause treatment. Find natural menopause relief with Winona. Start today","\u002Fhealth-quiz",{"url":2624,"title":2625,"description":2625},"https:\u002F\u002Fimages.ctfassets.net\u002Flyqt8dkk29ch\u002F4xCzI2vFazVvvAWsapEiP9\u002F6fd3415d1a70db28e1182ed1d9e202d4\u002Fimage-ad-1.webp?fm=webp","Start your custom, science-backed menopause treatment",{"url":2627,"title":2625,"description":2625},"https:\u002F\u002Fimages.ctfassets.net\u002Flyqt8dkk29ch\u002F3q15ulfsSU0OnBe3LAb0CX\u002F14196ecd7d97e6f40a3e3ec67226cac0\u002Fimage-ad-1-mobile.webp?fm=webp",{"sys":2629,"__typename":2630,"quote":2631,"title":2642,"backgroundColor":2643,"physician":2644},{"id":2364},"JournalsQuotes",{"json":2632},{"data":2633,"content":2634,"nodeType":385},{},[2635],{"data":2636,"content":2637,"nodeType":397},{},[2638],{"data":2639,"marks":2640,"value":2641,"nodeType":401},{},[],"Unlike systemic estrogen, vaginal estrogen is safe for all women to use, no matter if they still have their uterus or not. Vaginal estrogen cream is locally absorbed and helps to restore healthy tissue and a healthy microbiome of the vagina, and it reduces many symptoms of the genitourinary syndrome of menopause. When a patient uses vaginal estrogen cream alone, progesterone is not needed for endometrial protection due to the local absorption of the cream. It’s also safe for women to use vaginal estrogen in conjunction with systemic estrogen, but in that case, a woman with a uterus will need progesterone.","Dr. Cat Brown talks about vaginal estrogen with progesterone","Dark Cyan",{"sys":2645,"name":764,"slug":763,"credentials":765,"image":2646},{"id":762},{"url":767,"description":768},{"sys":2648,"__typename":2618,"title":2649,"slug":2650,"altText":2651,"url":2652,"desktopImage":2653,"mobileImage":2656},{"id":2536},"HRT Ad 3","hrt-ad-3","Experience the power of natural menopause relief. Say goodbye to your symptoms with Winona's HRT. Try Winona Today.","\u002Ftreatments",{"url":2654,"title":2655,"description":439},"https:\u002F\u002Fimages.ctfassets.net\u002Flyqt8dkk29ch\u002F7rBtyhcAoAB4M2qPsqF8e0\u002Fc124606521f114ef85c08dac9b79760e\u002Fhrt-ad-3-desktop.png?fm=webp","hrt-ad-3-desktop",{"url":2657,"title":2658,"description":439},"https:\u002F\u002Fimages.ctfassets.net\u002Flyqt8dkk29ch\u002F7KRomTWeZ9n873wrhRisZt\u002F439b550005f7de3411498471710162e2\u002Fhrt-ad-3-mobile.png?fm=webp","hrt-ad-3-mobile"]