How does HRT work in the body?

HRT works by supplementing the body's natural hormone levels that decline with age.

Estrogen: Estrogen circulates in the bloodstream, where it binds to estrogen receptors on cells in target tissues. This binding activates the receptors and affects the expression of specific genes, leading to changes in cell function. These changes can offset the effects of decreased estrogen that occur during menopause, therefore alleviating symptoms.

Progesterone: Similarly, progesterone circulates in the bloodstream and binds to progesterone receptors in target tissues like the uterus, breast, and brain, helping to offset the effects of decreased progesterone.

DHEA: DHEA is a hormone precursor produced by the adrenal glands that is broken down into estrogen and testosterone. When taken as a supplement, it enters the bloodstream and various cells throughout the body. The mechanism of action of DHEA within cells is complex and multifaceted, but one primary function is its conversion into other hormones. DHEA can help maintain estrogen levels by providing an alternative source of the hormone.

By supplementing with estrogen, progesterone, and DHEA, when necessary, HRT can help alleviate the symptoms of menopause and improve the quality of life for many women.